Senataxin helicase, the causal gene defect in ALS4, is a significant modifier of C9orf72 ALS G4C2 and arginine-containing dipeptide repeat toxicity. - Bennett, Craig L.; Dastidar, Somasish; Arnold, Frederick J.; McKinstry, Spencer U.; Stockford, Cameron; Freibaum, Brian D.; Sopher, Bryce L.; Wu, Meilin; Seidner, Glen; Joiner, William; Taylor, J. Paul; West, Ryan J. H.; et al. (Acta Neuropathologica Communications, 2023)