Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy.

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Title: Total and Free Blood and Plasma Concentration Changes in Pregnancy for Medicines Highly Bound to Plasma Proteins: Application of Physiologically Based Pharmacokinetic Modelling to Understand the Impact on Efficacy.
Authors: Coppola, Paola1 (AUTHOR) paola.coppola@certara.com, Butler, Andrew1 (AUTHOR) andrew.butler@mhra.gov.uk, Cole, Susan1 (AUTHOR), Kerwash, Essam1 (AUTHOR)
Source: Pharmaceutics. Oct2023, Vol. 15 Issue 10, p2455. 14p.
Database: Academic Search Ultimate
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ISSN:19994923
DOI:10.3390/pharmaceutics15102455