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A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.

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Title: A Minimal PBPK/PD Model with Expansion-Enhanced Target-Mediated Drug Disposition to Support a First-in-Human Clinical Study Design for a FLT3L-Fc Molecule.
Authors: Hosseini, Iraj1 (AUTHOR) hosseini.iraj@gene.com, Fleisher, Brett1 (AUTHOR), Getz, Jennifer1 (AUTHOR) fleisheb@gene.com, Decalf, Jérémie1 (AUTHOR), Kwong, Mandy1 (AUTHOR), Ovacik, Meric1 (AUTHOR), Bainbridge, Travis W.1 (AUTHOR), Moussion, Christine1 (AUTHOR), Rao, Gautham K.1 (AUTHOR), Gadkar, Kapil1 (AUTHOR), Kamath, Amrita V.1 (AUTHOR), Ramanujan, Saroja1 (AUTHOR)
Source: Pharmaceutics. May2024, Vol. 16 Issue 5, p660. 18p.
Database: Academic Search Ultimate
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              Text: May2024
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