Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription.

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Title: Repurposing of phosphodiesterase-5 inhibitor sildenafil as a therapeutic agent to prevent gastric cancer growth through suppressing c-MYC stability for IL-6 transcription.
Authors: Zhang, Zhenzhan1 (AUTHOR), Huang, Wuqing2 (AUTHOR), Huang, Donghua3 (AUTHOR), Xu, Zhou1 (AUTHOR), Xie, Qingfeng1 (AUTHOR), Tan, Xin1 (AUTHOR), He, Wenjun1 (AUTHOR), Yang, Weihao1 (AUTHOR), Li, Guoxin1 (AUTHOR) gzliguoxin@163.com, Ji, Jianguang4 (AUTHOR) jianguangji@um.edu.mo, Liu, Hao1 (AUTHOR) liuhaofbi@163.com
Source: Communications Biology. 1/18/2025, Vol. 8 Issue 1, p1-14. 14p.
Database: Academic Search Ultimate
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ISSN:23993642
DOI:10.1038/s42003-025-07519-9