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Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism.

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Title: Rescue of in vitro models of CSF1R-related adult-onset leukodystrophy by iluzanebart: mechanisms and therapeutic implications of TREM2 agonism.
Authors: Larson, Kelley C.1 (AUTHOR) klarson@vigilneuro.com, Gergits, Frederick W.1 (AUTHOR), Renoux, Abigail J.1 (AUTHOR), Weisman, Elizabeth J.1 (AUTHOR), Dejanovic, Borislav1 (AUTHOR), Huang, Liyue1 (AUTHOR), Pandya, Bhaumik1 (AUTHOR), McLaren, Donald G.1 (AUTHOR), Lynch, Berkley A.2 (AUTHOR), Fisher, Richard3 (AUTHOR), Thackaberry, Evan1 (AUTHOR), Gray, David1 (AUTHOR), Gaudreault, Francois1 (AUTHOR), Mirescu, Christian1 (AUTHOR)
Source: Journal of Neuroinflammation. 1/31/2025, Vol. 22 Issue 1, p1-21. 21p.
Database: Academic Search Ultimate
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ISSN:17422094
DOI:10.1186/s12974-025-03346-1