A defining member of the new cysteine-cradle family is an aECM protein signalling skin damage in C. elegans. - Sonntag, Thomas; Omi, Shizue; Andreeva, Antonina; Valotteau, Claire; Eichelbrenner, Jeanne; Chisholm, Andrew D.; Ward, Jordan D.; Pujol, Nathalie (PLoS Genetics, 2025)