Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography.
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| Title: | Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography. |
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| Authors: | Grosjean, Harold1,2 (AUTHOR), Aimon, Anthony1,3 (AUTHOR), Hassell‐Hart, Storm4 (AUTHOR), Thompson, Warren1,3 (AUTHOR), Koekemoer, Lizbé5,6 (AUTHOR), Bennett, James5,6 (AUTHOR), Bradley, Anthony6 (AUTHOR), Anderson, Cameron2 (AUTHOR), Wild, Conor1,6 (AUTHOR), Bradshaw, William J.5 (AUTHOR), FitzGerald, Edward A.7 (AUTHOR), Krojer, Tobias6 (AUTHOR), Fedorov, Oleg6 (AUTHOR), Biggin, Philip C.2 (AUTHOR), Spencer, John4,8 (AUTHOR) j.spencer@sussex.ac.uk, von Delft, Frank1,3,5,6,9 (AUTHOR) frank.vondelft@cmd.ox.ac.uk |
| Source: | Angewandte Chemie. 4/11/2025, Vol. 137 Issue 16, p1-15. 15p. |
| Database: | Academic Search Ultimate |
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| ISSN: | 00448249 |
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| DOI: | 10.1002/ange.202424373 |
