The de novo DNA methyltransferase 3B is a novel epigenetic regulator of MYC in multiple myeloma, representing a promising therapeutic target to counter relapse. - Muylaert, Catharina; Van Hemelrijck, Lien Ann; Van der Vreken, Arne; Heestermans, Robbe; Satilmis, Hatice; Verheye, Emma; Alaterre, Elina; Olsen, Catharina; De Beule, Nathan; De Veirman, Kim; Menu, Eline; Vanderkerken, Karin; et al. (Journal of Experimental & Clinical Cancer Research (17569966), 2025)