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A randomized phase II/III study of paclitaxel/carboplatin/metformin versus paclitaxel/carboplatin/placebo as initial therapy for measurable stage III or IVA, stage IVB, or recurrent endometrial cancer: An NRG oncology/GOG study.

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Title: A randomized phase II/III study of paclitaxel/carboplatin/metformin versus paclitaxel/carboplatin/placebo as initial therapy for measurable stage III or IVA, stage IVB, or recurrent endometrial cancer: An NRG oncology/GOG study.
Authors: Bae-Jump, Victoria L.1,2 (AUTHOR) victoria_baejump@med.unc.edu, Sill, Michael W.3 (AUTHOR) SillM@NRGOncology.org, Gehrig, Paola A.4 (AUTHOR) PAM7W@uvahealth.org, Merker, Jason D.2 (AUTHOR) jason_merker@med.unc.edu, Corcoran, David L.2 (AUTHOR) David.Corcoran@unc.edu, Pfefferle, Adam D.2 (AUTHOR) adamp@email.unc.edu, Hayward, Michele C.2 (AUTHOR) michele_hayward@med.unc.edu, Walker, Joan L.5 (AUTHOR) Walker@ouhsc.edu, Hagemann, Andrea R.6 (AUTHOR) hagemanna@wustl.edu, Waggoner, Steven E.7 (AUTHOR) WAGGONS@ccf.org, O'Cearbhaill, Roisin E.8 (AUTHOR) ocearbhr@mskcc.org, McDonald, Megan E.9 (AUTHOR) megan-e-mcdonald@uiowa.edu, Edelson, Mitchell I.10 (AUTHOR) Mitchell.edelson@jefferson.edu, DiSilvestro, Paul A.11 (AUTHOR) pdisilvestro@wihri.org, McNally, Amy L.12 (AUTHOR) amy.mcnally@usoncology.com, Fleury, Aimee13 (AUTHOR) afleury@wccenter.com, Littell, Ramey D.14 (AUTHOR) Ramey.Littell@kp.org, Ueland, Frederick R.15 (AUTHOR) Frederick.Ueland@uky.edu, Lankes, Heather A.16,17 (AUTHOR) LankesH@NRGOncology.org, Aghajanian, Carol8 (AUTHOR) aghajanc@mskcc.org
Source: Gynecologic Oncology. Apr2025, Vol. 195, p66-74. 9p.
Database: Academic Search Ultimate
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  Data: A randomized phase II/III study of paclitaxel/carboplatin/metformin versus paclitaxel/carboplatin/placebo as initial therapy for measurable stage III or IVA, stage IVB, or recurrent endometrial cancer: An NRG oncology/GOG study.
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        Value: 10.1016/j.ygyno.2025.03.003
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              Text: Apr2025
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