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A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade.

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Title: A hexamerization-enhanced, Fc-silenced agonistic CD27 antibody amplifies T-cell effector functions as single agent and in combination with PD-1 blockade.
Authors: Altıntaş, Işıl1 (AUTHOR), Nürmberger, Kristina B.2 (AUTHOR), Imle, Andrea2 (AUTHOR), Krause, Anna-Lena2 (AUTHOR), van Beuge, Marike M.1 (AUTHOR), Toker, Aras2 (AUTHOR), Ioan-Facsinay, Andreea1 (AUTHOR), Blum, Jordan3 (AUTHOR), Muik, Alexander2 (AUTHOR), Beurskens, Frank J.1 (AUTHOR), de Jong, Rob N.1 (AUTHOR), Satijn, David P. E.1 (AUTHOR), Gieseke, Friederike2 (AUTHOR), de Kreuk, Bart-Jan1 (AUTHOR), van der Kroef, Maarten1 (AUTHOR), Fellermeier-Kopf, Sina2 (AUTHOR), Ahmadi, Tahamtan3 (AUTHOR), Türeci, Özlem2 (AUTHOR), Breij, Esther C. W.1 (AUTHOR) ebreij@gmail.com, Şahin, Uğur2 (AUTHOR) ugur.sahin@biontech.de
Source: Scientific Reports. 7/24/2025, Vol. 15 Issue 1, p1-15. 15p.
Database: Academic Search Ultimate
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