The main protease (Mpro) from SARS-CoV-2 triggers plasma clotting in vitro by activating coagulation factors VII and FXII. - Pagotto, Anna; Uliana, Federico; Cavedon, Elena; Nordio, Giulia; Pierangelini, Andrea; Acquasaliente, Laura; Macchia, Maria Ludovica; Bellanda, Massimo; Gatto, Barbara; De Silvestro, Giustina; Marson, Piero; Gregori, Dario; et al. (Communications Biology, 2025)