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Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity.

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Title: Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity.
Authors: Jung, Okkeun1,2 (AUTHOR), Soto, Angelene3 (AUTHOR), Wolfe, Andrew L.2,3,4,5,6 (AUTHOR) awolfe@genectr.hunter.cuny.edu, Mahajan, Shahana S.1,2,3,5,7 (AUTHOR) smahajan@hunter.cuny.edu
Source: PLoS ONE. 8/8/2025, Vol. 20 Issue 8, p1-15. 15p.
Database: Academic Search Ultimate
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  Data: Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity.
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  Data: <searchLink fieldCode="AR" term="%22Jung%2C+Okkeun%22">Jung, Okkeun</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soto%2C+Angelene%22">Soto, Angelene</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wolfe%2C+Andrew+L%2E%22">Wolfe, Andrew L.</searchLink><relatesTo>2,3,4,5,6</relatesTo> (AUTHOR)<i> awolfe@genectr.hunter.cuny.edu</i><br /><searchLink fieldCode="AR" term="%22Mahajan%2C+Shahana+S%2E%22">Mahajan, Shahana S.</searchLink><relatesTo>1,2,3,5,7</relatesTo> (AUTHOR)<i> smahajan@hunter.cuny.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22PLoS+ONE%22">PLoS ONE</searchLink>. 8/8/2025, Vol. 20 Issue 8, p1-15. 15p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=187243424
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        Value: 10.1371/journal.pone.0329946
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        Text: English
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      – TitleFull: Daraxonrasib, a pan-RAS inhibitor, selectively inhibits osteosarcomas with activated KRAS by halting AKT signaling and matrix metalloprotease activity.
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              Text: 8/8/2025
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