Estrogen synthesized in the central nervous system enhances MC4R expression and reduces food intake. - Hayashi, Takanori; Kumamoto, Kanako; Kobayashi, Tatsuya; Hou, Xinfeng; Nagao, Shizuko; Harada, Nobuhiro; Honda, Shinichiro; Shimono, Yohei; Nishio, Eiji (FEBS Journal, 2025)