PPM1D is directly degraded by proteasomes in a ubiquitination-independent manner through its carboxyl-terminal region. - Takahashi, Masaki; Kondo, Takeshi; Kimura, Shogo; Nakazono, Akira; Yoshida, Shusei; Wada, Takeshi; Watanabe, Masashi; Hatakeyama, Shigetsugu (Journal of Biomedical Science, 2025)