Lactic acid produced by optimal vaginal Lactobacillus spp. potently and specifically inactivates HIV-1 in vitro by targeting the viral RNA genome and reverse transcriptase. - Aldunate, Muriel; Tyssen, David; Johnson, Adam; Latham, Catherine F.; Ellenberg, Paula; Cowieson, Nathan; Hayward, Joshua A.; Center, Rob J.; Ramsland, Paul A.; Hearps, Anna C.; Tachedjian, Gilda (PLoS Pathogens, 2025)