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LXR agonist rescues synaptic dysfunction and degeneration in SPG3A patient-specific iPSC-derived neurons.

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Title: LXR agonist rescues synaptic dysfunction and degeneration in SPG3A patient-specific iPSC-derived neurons.
Authors: Thakur, Gitika1 (AUTHOR), Dhanukate, Rutuja1 (AUTHOR), Mou, Yongchao1,2 (AUTHOR), Kunhiraman, Priya1 (AUTHOR), Khadilkar, Archana1 (AUTHOR), Srivastava, Siddharth3 (AUTHOR), Alecu, Julian E.3 (AUTHOR), Ebrahimi-Fakhari, Darius3 (AUTHOR), Chen, Zhenyu1,2 (AUTHOR), Blackstone, Craig4,5 (AUTHOR) cblackstone@mgh.harvard.edu, Li, Xue-Jun1,2 (AUTHOR) xjli23@uic.edu
Source: Acta Neuropathologica Communications. 11/17/2025, Vol. 13 Issue 1, p1-17. 17p.
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  Data: LXR agonist rescues synaptic dysfunction and degeneration in SPG3A patient-specific iPSC-derived neurons.
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  Data: <searchLink fieldCode="JN" term="%22Acta+Neuropathologica+Communications%22">Acta Neuropathologica Communications</searchLink>. 11/17/2025, Vol. 13 Issue 1, p1-17. 17p.
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        Value: 10.1186/s40478-025-02134-5
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              Text: 11/17/2025
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