1000TiP Novel next generation PARP1-selective and CNS penetrant inhibitor DSB2455: A phase Ia/Ib open label, multi-centre dose escalation study with expansion cohorts to assess the safety, tolerability, and activity as monotherapy in participants with advanced malignancies

Saved in:
Bibliographic Details
Title: 1000TiP Novel next generation PARP1-selective and CNS penetrant inhibitor DSB2455: A phase Ia/Ib open label, multi-centre dose escalation study with expansion cohorts to assess the safety, tolerability, and activity as monotherapy in participants with advanced malignancies
Authors: Yarza, R.1 (AUTHOR), Garralda, E.2 (AUTHOR), Sánchez Perez, V.3 (AUTHOR), De Velasco Oria, G.A.4 (AUTHOR), Lorusso, P.M.5 (AUTHOR), Rodríguez, R.M.6 (AUTHOR), Kristeleit, R.S.7 (AUTHOR), Ring, A.8 (AUTHOR), Yap, C.9 (AUTHOR), Rekowski, J.10 (AUTHOR), Dickinson, P.11 (AUTHOR), Ruston, L.12 (AUTHOR), Mcguinness, B.13 (AUTHOR), Cowley, P.13 (AUTHOR), Campbell, G.14 (AUTHOR), Wise, A.15 (AUTHOR), Thomson, C.13 (AUTHOR), Landers, D.16 (AUTHOR), Yap, T.A.17 (AUTHOR)
Source: Annals of Oncology. 2025 Supplement 2, Vol. 36, pS653-S653. 1p.
Database: Academic Search Ultimate
FullText Text:
  Availability: 0
Header DbId: asn
DbLabel: Academic Search Ultimate
An: 189419381
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: 1000TiP Novel next generation PARP1-selective and CNS penetrant inhibitor DSB2455: A phase Ia/Ib open label, multi-centre dose escalation study with expansion cohorts to assess the safety, tolerability, and activity as monotherapy in participants with advanced malignancies
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Yarza%2C+R%2E%22">Yarza, R.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Garralda%2C+E%2E%22">Garralda, E.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sánchez+Perez%2C+V%2E%22">Sánchez Perez, V.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Velasco+Oria%2C+G%2EA%2E%22">De Velasco Oria, G.A.</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lorusso%2C+P%2EM%2E%22">Lorusso, P.M.</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rodríguez%2C+R%2EM%2E%22">Rodríguez, R.M.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kristeleit%2C+R%2ES%2E%22">Kristeleit, R.S.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ring%2C+A%2E%22">Ring, A.</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yap%2C+C%2E%22">Yap, C.</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rekowski%2C+J%2E%22">Rekowski, J.</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Dickinson%2C+P%2E%22">Dickinson, P.</searchLink><relatesTo>11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ruston%2C+L%2E%22">Ruston, L.</searchLink><relatesTo>12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Mcguinness%2C+B%2E%22">Mcguinness, B.</searchLink><relatesTo>13</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cowley%2C+P%2E%22">Cowley, P.</searchLink><relatesTo>13</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Campbell%2C+G%2E%22">Campbell, G.</searchLink><relatesTo>14</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wise%2C+A%2E%22">Wise, A.</searchLink><relatesTo>15</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Thomson%2C+C%2E%22">Thomson, C.</searchLink><relatesTo>13</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Landers%2C+D%2E%22">Landers, D.</searchLink><relatesTo>16</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yap%2C+T%2EA%2E%22">Yap, T.A.</searchLink><relatesTo>17</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Annals+of+Oncology%22">Annals of Oncology</searchLink>. 2025 Supplement 2, Vol. 36, pS653-S653. 1p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=189419381
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.annonc.2025.08.1569
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 1
        StartPage: S653
    Titles:
      – TitleFull: 1000TiP Novel next generation PARP1-selective and CNS penetrant inhibitor DSB2455: A phase Ia/Ib open label, multi-centre dose escalation study with expansion cohorts to assess the safety, tolerability, and activity as monotherapy in participants with advanced malignancies
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Yarza, R.
      – PersonEntity:
          Name:
            NameFull: Garralda, E.
      – PersonEntity:
          Name:
            NameFull: Sánchez Perez, V.
      – PersonEntity:
          Name:
            NameFull: De Velasco Oria, G.A.
      – PersonEntity:
          Name:
            NameFull: Lorusso, P.M.
      – PersonEntity:
          Name:
            NameFull: Rodríguez, R.M.
      – PersonEntity:
          Name:
            NameFull: Kristeleit, R.S.
      – PersonEntity:
          Name:
            NameFull: Ring, A.
      – PersonEntity:
          Name:
            NameFull: Yap, C.
      – PersonEntity:
          Name:
            NameFull: Rekowski, J.
      – PersonEntity:
          Name:
            NameFull: Dickinson, P.
      – PersonEntity:
          Name:
            NameFull: Ruston, L.
      – PersonEntity:
          Name:
            NameFull: Mcguinness, B.
      – PersonEntity:
          Name:
            NameFull: Cowley, P.
      – PersonEntity:
          Name:
            NameFull: Campbell, G.
      – PersonEntity:
          Name:
            NameFull: Wise, A.
      – PersonEntity:
          Name:
            NameFull: Thomson, C.
      – PersonEntity:
          Name:
            NameFull: Landers, D.
      – PersonEntity:
          Name:
            NameFull: Yap, T.A.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 02
              M: 09
              Text: 2025 Supplement 2
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 09237534
          Numbering:
            – Type: volume
              Value: 36
          Titles:
            – TitleFull: Annals of Oncology
              Type: main
ResultId 1