Phase Ib and dose-expansion study of GSK3326595, a PRMT5 inhibitor as monotherapy and in combination with pembrolizumab in patients with advanced cancers.
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| Title: | Phase Ib and dose-expansion study of GSK3326595, a PRMT5 inhibitor as monotherapy and in combination with pembrolizumab in patients with advanced cancers. |
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| Authors: | Gounder, M.M.1,2 (AUTHOR), Martin-Romano, P.3 (AUTHOR), Italiano, A.4,5 (AUTHOR), Siu, L.L.6 (AUTHOR), Cassier, P.A.7 (AUTHOR), Falchook, G.S.8 (AUTHOR), Lossos, I.S.9 (AUTHOR), Rasco, D.W.10 (AUTHOR), Hilton, J.F.11 (AUTHOR), McKean, M.A.12 (AUTHOR), Opdam, F.L.13 (AUTHOR), Strauss, J.14 (AUTHOR), De Jonge, M.15 (AUTHOR), Vermaat, J.S.P.16 (AUTHOR), Crossman, T.17 (AUTHOR), Zajac, M.17 (AUTHOR), Tarkar, A.18 (AUTHOR), Gonzalez Carreras, F.19 (AUTHOR), Kremer, B.E.1,18 (AUTHOR) brandon.e.kremer@gsk.com, Barbash, O.18 (AUTHOR) |
| Source: | Annals of Oncology. Dec2025, Vol. 36 Issue 12, p1480-1491. 12p. |
| Database: | Academic Search Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: asn DbLabel: Academic Search Ultimate An: 189761535 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Phase Ib and dose-expansion study of GSK3326595, a PRMT5 inhibitor as monotherapy and in combination with pembrolizumab in patients with advanced cancers. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Gounder%2C+M%2EM%2E%22">Gounder, M.M.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Martin-Romano%2C+P%2E%22">Martin-Romano, P.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Italiano%2C+A%2E%22">Italiano, A.</searchLink><relatesTo>4,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Siu%2C+L%2EL%2E%22">Siu, L.L.</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cassier%2C+P%2EA%2E%22">Cassier, P.A.</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Falchook%2C+G%2ES%2E%22">Falchook, G.S.</searchLink><relatesTo>8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lossos%2C+I%2ES%2E%22">Lossos, I.S.</searchLink><relatesTo>9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Rasco%2C+D%2EW%2E%22">Rasco, D.W.</searchLink><relatesTo>10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hilton%2C+J%2EF%2E%22">Hilton, J.F.</searchLink><relatesTo>11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McKean%2C+M%2EA%2E%22">McKean, M.A.</searchLink><relatesTo>12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Opdam%2C+F%2EL%2E%22">Opdam, F.L.</searchLink><relatesTo>13</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Strauss%2C+J%2E%22">Strauss, J.</searchLink><relatesTo>14</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22De+Jonge%2C+M%2E%22">De Jonge, M.</searchLink><relatesTo>15</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vermaat%2C+J%2ES%2EP%2E%22">Vermaat, J.S.P.</searchLink><relatesTo>16</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Crossman%2C+T%2E%22">Crossman, T.</searchLink><relatesTo>17</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zajac%2C+M%2E%22">Zajac, M.</searchLink><relatesTo>17</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tarkar%2C+A%2E%22">Tarkar, A.</searchLink><relatesTo>18</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gonzalez+Carreras%2C+F%2E%22">Gonzalez Carreras, F.</searchLink><relatesTo>19</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kremer%2C+B%2EE%2E%22">Kremer, B.E.</searchLink><relatesTo>1,18</relatesTo> (AUTHOR)<i> brandon.e.kremer@gsk.com</i><br /><searchLink fieldCode="AR" term="%22Barbash%2C+O%2E%22">Barbash, O.</searchLink><relatesTo>18</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Oncology%22">Annals of Oncology</searchLink>. Dec2025, Vol. 36 Issue 12, p1480-1491. 12p. |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=189761535 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.annonc.2025.08.3757 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1480 Titles: – TitleFull: Phase Ib and dose-expansion study of GSK3326595, a PRMT5 inhibitor as monotherapy and in combination with pembrolizumab in patients with advanced cancers. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Gounder, M.M. – PersonEntity: Name: NameFull: Martin-Romano, P. – PersonEntity: Name: NameFull: Italiano, A. – PersonEntity: Name: NameFull: Siu, L.L. – PersonEntity: Name: NameFull: Cassier, P.A. – PersonEntity: Name: NameFull: Falchook, G.S. – PersonEntity: Name: NameFull: Lossos, I.S. – PersonEntity: Name: NameFull: Rasco, D.W. – PersonEntity: Name: NameFull: Hilton, J.F. – PersonEntity: Name: NameFull: McKean, M.A. – PersonEntity: Name: NameFull: Opdam, F.L. – PersonEntity: Name: NameFull: Strauss, J. – PersonEntity: Name: NameFull: De Jonge, M. – PersonEntity: Name: NameFull: Vermaat, J.S.P. – PersonEntity: Name: NameFull: Crossman, T. – PersonEntity: Name: NameFull: Zajac, M. – PersonEntity: Name: NameFull: Tarkar, A. – PersonEntity: Name: NameFull: Gonzalez Carreras, F. – PersonEntity: Name: NameFull: Kremer, B.E. – PersonEntity: Name: NameFull: Barbash, O. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 12 Text: Dec2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 09237534 Numbering: – Type: volume Value: 36 – Type: issue Value: 12 Titles: – TitleFull: Annals of Oncology Type: main |
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