Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A.

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Title: Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A.
Authors: McBride, Christina M.1,2 (AUTHOR), McCauley, Morgan1 (AUTHOR), Harris, Natalia R.1,3 (AUTHOR), Amin, Sahar1,4 (AUTHOR), Curtis, Brian J.1 (AUTHOR), Verhey-Henke, Linnea1 (AUTHOR), Teklemichael, Awet A.5 (AUTHOR), Oliphant, Erin N.6 (AUTHOR), Dranchak, Patricia6 (AUTHOR), Lev, Katherine L.1,2 (AUTHOR), Qu, Fengrui7 (AUTHOR), Snodgrass, Harrison M.8 (AUTHOR), Lewis, Jared C.8 (AUTHOR) jcl3@iu.edu, Inglese, James6,9 (AUTHOR), Su, Xin-Zhuan5 (AUTHOR), Pereira, Filipa1,3 (AUTHOR) fpere@umich.edu, Sherman, David H.1,4,7,10 (AUTHOR) davidhs@umich.edu
Source: Communications Chemistry. 12/5/2025, Vol. 8 Issue 1, p1-12. 12p.
Database: Academic Search Ultimate
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ISSN:23993669
DOI:10.1038/s42004-025-01779-6