View in EDS HTML Full Text PDF Full Text

Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells.

Saved in:
Bibliographic Details
Title: Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells.
Authors: El-Wakil, Marwa H.1 (AUTHOR) marwa.elwakil@alexu.edu.eg, Ghazala, Rasha A.2 (AUTHOR), El-Dershaby, Hadeel A.1 (AUTHOR), Drozdowska, Danuta3 (AUTHOR), Wróbel-Tałałaj, Agnieszka3 (AUTHOR), Parzych, Cezary4 (AUTHOR), Ratkiewicz, Artur4 (AUTHOR), Kolesińska, Beata5 (AUTHOR), Abd El-Razik, Heba A.1 (AUTHOR), Soliman, Farid S. G.1 (AUTHOR)
Source: Journal of Enzyme Inhibition & Medicinal Chemistry. Dec2025, Vol. 40 Issue 1, p1-21. 21p.
Database: Academic Search Ultimate
Full text is not displayed to guests.
FullText Links:
  – Type: pdflink
Text:
  Availability: 1
Header DbId: asn
DbLabel: Academic Search Ultimate
An: 190283225
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22El-Wakil%2C+Marwa+H%2E%22">El-Wakil, Marwa H.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> marwa.elwakil@alexu.edu.eg</i><br /><searchLink fieldCode="AR" term="%22Ghazala%2C+Rasha+A%2E%22">Ghazala, Rasha A.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22El-Dershaby%2C+Hadeel+A%2E%22">El-Dershaby, Hadeel A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Drozdowska%2C+Danuta%22">Drozdowska, Danuta</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wróbel-Tałałaj%2C+Agnieszka%22">Wróbel-Tałałaj, Agnieszka</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Parzych%2C+Cezary%22">Parzych, Cezary</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ratkiewicz%2C+Artur%22">Ratkiewicz, Artur</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Kolesińska%2C+Beata%22">Kolesińska, Beata</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abd+El-Razik%2C+Heba+A%2E%22">Abd El-Razik, Heba A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Soliman%2C+Farid+S%2E+G%2E%22">Soliman, Farid S. G.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22Journal+of+Enzyme+Inhibition+%26+Medicinal+Chemistry%22">Journal of Enzyme Inhibition & Medicinal Chemistry</searchLink>. Dec2025, Vol. 40 Issue 1, p1-21. 21p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=190283225
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/14756366.2025.2468353
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 21
        StartPage: 1
    Titles:
      – TitleFull: Rational design, synthesis, and molecular modelling insights of dual DNA binders/DHFR inhibitors bearing arylidene-hydrazinyl-1,3-thiazole scaffold with apoptotic and anti-migratory potential in breast MCF-7 cancer cells.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: El-Wakil, Marwa H.
      – PersonEntity:
          Name:
            NameFull: Ghazala, Rasha A.
      – PersonEntity:
          Name:
            NameFull: El-Dershaby, Hadeel A.
      – PersonEntity:
          Name:
            NameFull: Drozdowska, Danuta
      – PersonEntity:
          Name:
            NameFull: Wróbel-Tałałaj, Agnieszka
      – PersonEntity:
          Name:
            NameFull: Parzych, Cezary
      – PersonEntity:
          Name:
            NameFull: Ratkiewicz, Artur
      – PersonEntity:
          Name:
            NameFull: Kolesińska, Beata
      – PersonEntity:
          Name:
            NameFull: Abd El-Razik, Heba A.
      – PersonEntity:
          Name:
            NameFull: Soliman, Farid S. G.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: Dec2025
              Type: published
              Y: 2025
          Identifiers:
            – Type: issn-print
              Value: 14756366
          Numbering:
            – Type: volume
              Value: 40
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Journal of Enzyme Inhibition & Medicinal Chemistry
              Type: main
ResultId 1