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IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy.

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Title: IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy.
Authors: Goala, Payal1,2, Yongliang Zhang3, Beatty, Nolan1,2, Pavy, Allan4, McSain, Shannon1, Sailer, Cooper1, Tariq, Muhammad Junaid4,5, Hamid, Showkat4,6, Gomez, Eduardo Cortes7, Jianmin Wang7, Massillon, Duna1, Ilecki, Maxwell4, Boucher, Justin C.8, Savid-Frontera, Constanza8, Sae Bom Lee2,8, Kotani, Hiroshi9, Stone, Meredith L.4, Jain, Michael D.6, Davila, Marco L.1,4 Marco.Davila@RoswellPark.org
Source: Journal of Clinical Investigation. 1/2/2026, Vol. 136 Issue 1, p1-17. 17p.
Database: Academic Search Ultimate
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DbLabel: Academic Search Ultimate
An: 190683065
AccessLevel: 2
PubType: Academic Journal
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PreciseRelevancyScore: 0
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  Data: IFN-γ-driven skewing towards Th1 over Th17 differentiation underlies CRS and neutropenia in CAR-T therapy.
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  Data: <searchLink fieldCode="AR" term="%22Goala%2C+Payal%22">Goala, Payal</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Yongliang+Zhang%22">Yongliang Zhang</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Beatty%2C+Nolan%22">Beatty, Nolan</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Pavy%2C+Allan%22">Pavy, Allan</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22McSain%2C+Shannon%22">McSain, Shannon</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Sailer%2C+Cooper%22">Sailer, Cooper</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Tariq%2C+Muhammad+Junaid%22">Tariq, Muhammad Junaid</searchLink><relatesTo>4,5</relatesTo><br /><searchLink fieldCode="AR" term="%22Hamid%2C+Showkat%22">Hamid, Showkat</searchLink><relatesTo>4,6</relatesTo><br /><searchLink fieldCode="AR" term="%22Gomez%2C+Eduardo+Cortes%22">Gomez, Eduardo Cortes</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Jianmin+Wang%22">Jianmin Wang</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Massillon%2C+Duna%22">Massillon, Duna</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ilecki%2C+Maxwell%22">Ilecki, Maxwell</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Boucher%2C+Justin+C%2E%22">Boucher, Justin C.</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Savid-Frontera%2C+Constanza%22">Savid-Frontera, Constanza</searchLink><relatesTo>8</relatesTo><br /><searchLink fieldCode="AR" term="%22Sae+Bom+Lee%22">Sae Bom Lee</searchLink><relatesTo>2,8</relatesTo><br /><searchLink fieldCode="AR" term="%22Kotani%2C+Hiroshi%22">Kotani, Hiroshi</searchLink><relatesTo>9</relatesTo><br /><searchLink fieldCode="AR" term="%22Stone%2C+Meredith+L%2E%22">Stone, Meredith L.</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Jain%2C+Michael+D%2E%22">Jain, Michael D.</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Davila%2C+Marco+L%2E%22">Davila, Marco L.</searchLink><relatesTo>1,4</relatesTo><i> Marco.Davila@RoswellPark.org</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Clinical+Investigation%22">Journal of Clinical Investigation</searchLink>. 1/2/2026, Vol. 136 Issue 1, p1-17. 17p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=190683065
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        Value: 10.1172/JCI194631
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        Text: English
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              Text: 1/2/2026
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              Y: 2026
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