The RPA-binding domain and the KKRK motif in Rad26ATRIP cooperate at the perturbed DNA replication fork for initiating checkpoint signalling. - Xu, Yong-jie; Gao, Anmin; Dev, Kamal; Zheng, Yuyuan; Alyahya, Mashael Y.; Pasam, Sairam; Kaur, Guramrit; Zhou, Chun (PLoS Genetics, 2026)