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A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry–based drug metabolite profiling.

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Title: A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry–based drug metabolite profiling.
Authors: Lin, Chang-Te1 (AUTHOR), Chiou, Yi-Shiou1,2,3 (AUTHOR), Yang, Ji-Rui4 (AUTHOR), Wang, Jie-Huei5 (AUTHOR), Yen, Meng-Chi6 (AUTHOR), Li, Cai-Rong7 (AUTHOR), Shih, Chia-Lung1,7 (AUTHOR) stone770116@gmail.com
Source: Talanta. Aug2026, Vol. 305, pN.PAG-N.PAG. 1p.
Database: Academic Search Ultimate
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  Availability: 0
Header DbId: asn
DbLabel: Academic Search Ultimate
An: 192588983
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry–based drug metabolite profiling.
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  Data: <searchLink fieldCode="AR" term="%22Lin%2C+Chang-Te%22">Lin, Chang-Te</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Chiou%2C+Yi-Shiou%22">Chiou, Yi-Shiou</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Ji-Rui%22">Yang, Ji-Rui</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Jie-Huei%22">Wang, Jie-Huei</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yen%2C+Meng-Chi%22">Yen, Meng-Chi</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Li%2C+Cai-Rong%22">Li, Cai-Rong</searchLink><relatesTo>7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shih%2C+Chia-Lung%22">Shih, Chia-Lung</searchLink><relatesTo>1,7</relatesTo> (AUTHOR)<i> stone770116@gmail.com</i>
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  Data: <searchLink fieldCode="JN" term="%22Talanta%22">Talanta</searchLink>. Aug2026, Vol. 305, pN.PAG-N.PAG. 1p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=192588983
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.talanta.2026.129582
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 1
        StartPage: N.PAG
    Titles:
      – TitleFull: A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry–based drug metabolite profiling.
        Type: main
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      – PersonEntity:
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            NameFull: Lin, Chang-Te
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            NameFull: Chiou, Yi-Shiou
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            NameFull: Yang, Ji-Rui
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            NameFull: Wang, Jie-Huei
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            NameFull: Yen, Meng-Chi
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            NameFull: Li, Cai-Rong
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            NameFull: Shih, Chia-Lung
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          Dates:
            – D: 01
              M: 08
              Text: Aug2026
              Type: published
              Y: 2026
          Identifiers:
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              Value: 00399140
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              Value: 305
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