A systematically optimized two-dose differential strategy integrating stable isotope tracing and mass shift defect filtering for reducing false positives in high-resolution mass spectrometry–based drug metabolite profiling. - Lin, Chang-Te; Chiou, Yi-Shiou; Yang, Ji-Rui; Wang, Jie-Huei; Yen, Meng-Chi; Li, Cai-Rong; Shih, Chia-Lung (Talanta, 2026)