Combined radiomics, PI-RADS, and clinical model improve significant prostate cancer prediction and guide biopsy decision. - Antolin, Andreu; Mast, Richard; Roson, Nuria; Arce, Javier; Almodovar, Ramon; Cortada, Roger; Alberti, Anna; Miro, Berta; Mendez, Olga; Maceda, Almudena; Serrano, Esther; Pietro-de-la-Lastra, Carmen; et al. (Insights into Imaging, 2026)