Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice.

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Title: Host species-specific mutations in the thumb domain of the 3Dpol polymerase are required for efficient replication of human hepatitis A virus in mice.
Authors: Misumi, Ichiro1 (AUTHOR), Shirasaki, Takayoshi2 (AUTHOR), Xie, Ling3 (AUTHOR), Yonish, Bryan4 (AUTHOR), González-López, Olga2 (AUTHOR), Hirai-Yuki, Asuka2 (AUTHOR), Chen, Xian3,4 (AUTHOR), Li, You5 (AUTHOR), Whitmire, Jason K.1,2,4 (AUTHOR), Lemon, Stanley M.2,4,6 (AUTHOR) smlemon@med.unc.edu
Source: PLoS Pathogens. 5/11/2026, Vol. 22 Issue 5, p1-23. 23p.
Database: Academic Search Ultimate
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ISSN:15537366
DOI:10.1371/journal.ppat.1014213