Aging diminishes thymic output, reduces naive T cells, promotes memory T-cell accumulation, and impairs thymic regeneration. - Konovalova, Daria M.; Cooper, Madison D.; Huang, Shuli; Shane, Danielle X.; Mulhern, Jordyn S.; Chiao, Ying Ann; Yuan, Sarah Y.; Ma, Yonggang (American Journal of Physiology: Regulatory, Integrative & Comparative Physiology, 2026)