Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs.

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Title: Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs.
Authors: Ippolito, Aurelija1 (AUTHOR) aurelija.ippolito@univ.ox.ac.uk, Vasudevan, Sridhar1 (AUTHOR), Hurley, Shaun2 (AUTHOR), Gilmour, Gary2 (AUTHOR), Westhorpe, Frederick2 (AUTHOR), Churchill, Grant1 (AUTHOR), Sharp, Trevor1 (AUTHOR) trevor.sharp@pharm.ox.ac.uk
Source: British Journal of Pharmacology. Jul2026, Vol. 183 Issue 14, p4058-4071. 14p.
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  Data: Evidence that 5‐HT<subscript>2A</subscript> receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs.
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  Data: <searchLink fieldCode="AR" term="%22Ippolito%2C+Aurelija%22">Ippolito, Aurelija</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> aurelija.ippolito@univ.ox.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Vasudevan%2C+Sridhar%22">Vasudevan, Sridhar</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hurley%2C+Shaun%22">Hurley, Shaun</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gilmour%2C+Gary%22">Gilmour, Gary</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Westhorpe%2C+Frederick%22">Westhorpe, Frederick</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Churchill%2C+Grant%22">Churchill, Grant</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sharp%2C+Trevor%22">Sharp, Trevor</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> trevor.sharp@pharm.ox.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22British+Journal+of+Pharmacology%22">British Journal of Pharmacology</searchLink>. Jul2026, Vol. 183 Issue 14, p4058-4071. 14p.
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=asn&AN=194753603
RecordInfo BibRecord:
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      – Type: doi
        Value: 10.1111/bph.70109
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      – Code: eng
        Text: English
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        PageCount: 14
        StartPage: 4058
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      – TitleFull: Evidence that 5‐HT2A receptor signalling efficacy and not biased agonism differentiates serotonergic psychedelic from non‐psychedelic drugs.
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            NameFull: Ippolito, Aurelija
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            NameFull: Vasudevan, Sridhar
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            NameFull: Hurley, Shaun
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            NameFull: Gilmour, Gary
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            NameFull: Westhorpe, Frederick
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            NameFull: Churchill, Grant
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            – D: 15
              M: 07
              Text: Jul2026
              Type: published
              Y: 2026
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            – TitleFull: British Journal of Pharmacology
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