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Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2′deoxyribose (IPdR) × 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.

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Title: Toxicology and pharmacokinetic study of orally administered 5-iodo-2-pyrimidinone-2′deoxyribose (IPdR) × 28 days in Fischer-344 rats: impact on the initial clinical phase I trial design of IPdR-mediated radiosensitization.
Authors: Kinsella, Timothy J.1,2 timothy.kinsella@UHhospitals.org, Kinsella, Michael T.1, Seongwon Hong3, Johnson, Jerry P.3, Burback, Brian3, Tosca, Patricia J.3
Source: Cancer Chemotherapy & Pharmacology. Feb2008, Vol. 61 Issue 2, p323-334. 12p. 1 Diagram, 4 Charts, 4 Graphs.
Database: Academic Search Ultimate
Description
ISSN:03445704
DOI:10.1007/s00280-007-0518-4