Preeclampsia and Fetal Growth: Influence of Infant Sex
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| Title: | Preeclampsia and Fetal Growth: Influence of Infant Sex |
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| Authors: | Reynolds, Simone Alphea |
| Summary: | In response to in utero insults, male vs. female infants have greater disadvantages in pregnancy outcome. We asked if this differential impact of fetal sex might extend to fetal growth in utero during preeclampsia. We first investigated the influence of relevant variables in normotensive pregnancy. We evaluated whether the impact of maternal pre-pregnancy body mass index (BMI), smoking and socioeconomic status were modified by sex and/or race in singleton offspring of 8,801 primiparous normotensive women enrolled in the Collaborative Perinatal Project. The mean head-to-chest circumference (HCC) decreased more or each 1kg/m2 increase in pre-pregnancy BMI, while mean birthweight and ponderal index (PI) increased more for each 1kg/m2 increase in pre-pregnancy BMI among term females vs. males (p=0.07, p |
| URL: | http://d-scholarship.pitt.edu/8410/1/Reynolds_dissertation_7-17-11_updated.pdf |
| Database: | OpenDissertations |
| Abstract: | In response to in utero insults, male vs. female infants have greater disadvantages in pregnancy outcome. We asked if this differential impact of fetal sex might extend to fetal growth in utero during preeclampsia. We first investigated the influence of relevant variables in normotensive pregnancy. We evaluated whether the impact of maternal pre-pregnancy body mass index (BMI), smoking and socioeconomic status were modified by sex and/or race in singleton offspring of 8,801 primiparous normotensive women enrolled in the Collaborative Perinatal Project. The mean head-to-chest circumference (HCC) decreased more or each 1kg/m2 increase in pre-pregnancy BMI, while mean birthweight and ponderal index (PI) increased more for each 1kg/m2 increase in pre-pregnancy BMI among term females vs. males (p=0.07, p |
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