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Synthesis and cytotoxicity of azaheterocyclic compounds

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Title: Synthesis and cytotoxicity of azaheterocyclic compounds
Authors: Pandya, Keyur M.
Committee Members: Jonnalagadda, Subash; Ramanujachary, Kandalam; Wu, Chun
Summary: Multicomponent coupling reactions (MCRs) have been known for a long time and one such reaction that utilizes isocyanides is Passerini reaction. It is a powerful tool to synthesize libraries of different compounds. Azaheterocyclic compounds play an important role in medicinal chemistry. Motifs such as imidazoles, piperazines, pyrazoles, pyridines, triazoles, etc. are routinely observed in several compounds of pharmacological interest. Several natural products also contain these motifs in them. We have undertaken a library synthesis of heterocyclic molecules driven by our group's long-standing interest of synthesizing medicinally relevant small molecules employing green chemistry techniques. This thesis details our efforts on the development of novel synthetic methodologies for the synthesis of functionalized azaheterocyclic compounds as potential anti-cancer agents. We initiated the synthesis of these compounds employing Passerini reaction as the key step. The biological evaluation of these synthetic derivatives showed some promise as anti-cancer agents.
URL: https://rdw.rowan.edu/etd/2549
Database: OpenDissertations
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Header DbId: ddu
DbLabel: OpenDissertations
An: ddu.oai.rdw.rowan.edu.etd.3551
AccessLevel: 6
PubType: Dissertation/ Thesis
PubTypeId: dissertation
PreciseRelevancyScore: 0
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  Group: Ti
  Data: Synthesis and cytotoxicity of azaheterocyclic compounds
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  Data: <searchLink fieldCode="AR" term="%22Pandya%2C+Keyur+M%2E%22">Pandya, Keyur M.</searchLink>
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  Data: <searchLink fieldCode="CO" term="%22Jonnalagadda%2C+Subash%22">Jonnalagadda, Subash</searchLink>; <searchLink fieldCode="CO" term="%22Ramanujachary%2C+Kandalam%22">Ramanujachary, Kandalam</searchLink>; <searchLink fieldCode="CO" term="%22Wu%2C+Chun%22">Wu, Chun</searchLink>
– Name: Abstract
  Label: Summary
  Group: Ab
  Data: Multicomponent coupling reactions (MCRs) have been known for a long time and one such reaction that utilizes isocyanides is Passerini reaction. It is a powerful tool to synthesize libraries of different compounds. Azaheterocyclic compounds play an important role in medicinal chemistry. Motifs such as imidazoles, piperazines, pyrazoles, pyridines, triazoles, etc. are routinely observed in several compounds of pharmacological interest. Several natural products also contain these motifs in them. We have undertaken a library synthesis of heterocyclic molecules driven by our group's long-standing interest of synthesizing medicinally relevant small molecules employing green chemistry techniques. This thesis details our efforts on the development of novel synthetic methodologies for the synthesis of functionalized azaheterocyclic compounds as potential anti-cancer agents. We initiated the synthesis of these compounds employing Passerini reaction as the key step. The biological evaluation of these synthetic derivatives showed some promise as anti-cancer agents.
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RecordInfo BibRecord:
  BibEntity:
    Languages:
      – Code: eng
        Text: English
    Subjects:
      – SubjectFull: Passerini reaction
        Type: general
      – SubjectFull: azaheterocyclic compounds
        Type: general
      – SubjectFull: multicomponent coupling reactions
        Type: general
      – SubjectFull: anti-cancer agents
        Type: general
      – SubjectFull: synthesis
        Type: general
      – SubjectFull: green chemistry
        Type: general
      – SubjectFull: Pharmaceutical chemistry; Organic compounds--Synthesis
        Type: general
      – SubjectFull: Medicinal and Pharmaceutical Chemistry
        Type: general
      – SubjectFull: Pharmacy and Pharmaceutical Sciences
        Type: general
    Titles:
      – TitleFull: Synthesis and cytotoxicity of azaheterocyclic compounds
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pandya, Keyur M.
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Type: published
              Y: 2018
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