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Stable vesicle assemblies on surfaces of hydrogel nanoparticles formed from a polysaccharide modified with lipid moieties.

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Title: Stable vesicle assemblies on surfaces of hydrogel nanoparticles formed from a polysaccharide modified with lipid moieties.
Authors: Kang, Insung1, Yoon, Jungju1, Lee, Yebin1, Choi, Jaehyuk1, Yang, Jinho1, Chang, Suk Tai1, Lee, Jonghwi1, Lee, Jaehwi2, Yoo, Pil J.3, Park, Juhyun1 jpark@cau.ac.kr
Source: Chemical Engineering Journal. Mar2015, Vol. 263, p38-44. 7p.
Subjects: Vesicles (Cytology), Surface chemistry, Hydrogels, Polysaccharides, Nanomedicine, Lipids, Moieties (Chemistry)
Abstract: Micro- and nanoparticle-supported lipid assemblies have significant potential for being used in biology and medicine for sensing, mimicking cellular membranes, and delivering drugs or cosmetic agents. Here, we introduce a new type of nanohydrogels based on the modification of a polysaccharide with lipid moieties, followed by the formation of nanoparticles and assembling lipid bilayers on the particle surfaces. The lipophilic compound 1,2-ditetradecanoyl- sn -glycero-3-phosphoethanolamine (DMPE) and the UV-crosslinkable methacrylic anhydride were covalently attached to hyaluronic acid (HA) and the formation of hydrogel nanoparticles via a surfactant-free inverse emulsion mechanism was demonstrated. As an anchoring group, the lipophilic DMPE moiety enables the formation of hydrogel nanoparticles with a spherical morphology in nonpolar media and allows for the stable assembly of lipid bilayers bearing amphiphiles on HA nanohydrogel surfaces. The conjugated oligoelectrolyte, 4,4′-bis[4′-( N , N -bis(6″-( N , N , N -trimethylammonium)hexyl)amino)styryl] stilbene tetraiodide (DSSN+), was incorporated into the nanohydrogel-supported lipid bilayers, resulting in the formation of stable multilamellar peripheral vesicular structures due to the similarity in chemical structure of DMPE and the assembled lipid molecules. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 100249862
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Data: Stable vesicle assemblies on surfaces of hydrogel nanoparticles formed from a polysaccharide modified with lipid moieties.
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  Data: <searchLink fieldCode="AR" term="%22Kang%2C+Insung%22">Kang, Insung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yoon%2C+Jungju%22">Yoon, Jungju</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Yebin%22">Lee, Yebin</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Choi%2C+Jaehyuk%22">Choi, Jaehyuk</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Yang%2C+Jinho%22">Yang, Jinho</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Chang%2C+Suk+Tai%22">Chang, Suk Tai</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Jonghwi%22">Lee, Jonghwi</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lee%2C+Jaehwi%22">Lee, Jaehwi</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Yoo%2C+Pil+J%2E%22">Yoo, Pil J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Park%2C+Juhyun%22">Park, Juhyun</searchLink><relatesTo>1</relatesTo><i> jpark@cau.ac.kr</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Engineering+Journal%22">Chemical Engineering Journal</searchLink>. Mar2015, Vol. 263, p38-44. 7p.
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  Data: <searchLink fieldCode="DE" term="%22Vesicles+%28Cytology%29%22">Vesicles (Cytology)</searchLink><br /><searchLink fieldCode="DE" term="%22Surface+chemistry%22">Surface chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Hydrogels%22">Hydrogels</searchLink><br /><searchLink fieldCode="DE" term="%22Polysaccharides%22">Polysaccharides</searchLink><br /><searchLink fieldCode="DE" term="%22Nanomedicine%22">Nanomedicine</searchLink><br /><searchLink fieldCode="DE" term="%22Lipids%22">Lipids</searchLink><br /><searchLink fieldCode="DE" term="%22Moieties+%28Chemistry%29%22">Moieties (Chemistry)</searchLink>
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  Data: Micro- and nanoparticle-supported lipid assemblies have significant potential for being used in biology and medicine for sensing, mimicking cellular membranes, and delivering drugs or cosmetic agents. Here, we introduce a new type of nanohydrogels based on the modification of a polysaccharide with lipid moieties, followed by the formation of nanoparticles and assembling lipid bilayers on the particle surfaces. The lipophilic compound 1,2-ditetradecanoyl- sn -glycero-3-phosphoethanolamine (DMPE) and the UV-crosslinkable methacrylic anhydride were covalently attached to hyaluronic acid (HA) and the formation of hydrogel nanoparticles via a surfactant-free inverse emulsion mechanism was demonstrated. As an anchoring group, the lipophilic DMPE moiety enables the formation of hydrogel nanoparticles with a spherical morphology in nonpolar media and allows for the stable assembly of lipid bilayers bearing amphiphiles on HA nanohydrogel surfaces. The conjugated oligoelectrolyte, 4,4′-bis[4′-( N , N -bis(6″-( N , N , N -trimethylammonium)hexyl)amino)styryl] stilbene tetraiodide (DSSN+), was incorporated into the nanohydrogel-supported lipid bilayers, resulting in the formation of stable multilamellar peripheral vesicular structures due to the similarity in chemical structure of DMPE and the assembled lipid molecules. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
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  Data: <i>Copyright of Chemical Engineering Journal is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1016/j.cej.2014.10.096
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      – Code: eng
        Text: English
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      Pagination:
        PageCount: 7
        StartPage: 38
    Subjects:
      – SubjectFull: Vesicles (Cytology)
        Type: general
      – SubjectFull: Surface chemistry
        Type: general
      – SubjectFull: Hydrogels
        Type: general
      – SubjectFull: Polysaccharides
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      – SubjectFull: Nanomedicine
        Type: general
      – SubjectFull: Lipids
        Type: general
      – SubjectFull: Moieties (Chemistry)
        Type: general
    Titles:
      – TitleFull: Stable vesicle assemblies on surfaces of hydrogel nanoparticles formed from a polysaccharide modified with lipid moieties.
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            NameFull: Kang, Insung
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            – D: 01
              M: 03
              Text: Mar2015
              Type: published
              Y: 2015
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