Primary hepatic angiosarcoma: multi-institutional comprehensive cancer centre review of multiphasic CT and MR imaging in 35 patients.
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| Title: | Primary hepatic angiosarcoma: multi-institutional comprehensive cancer centre review of multiphasic CT and MR imaging in 35 patients. |
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| Authors: | Pickhardt, Perry1 ppickhardt2@uwhealth.org, Kitchin, Douglas1, Lubner, Meghan1, Ganeshan, Dhakshina2, Bhalla, Sanjeev3, Covey, Anne4 |
| Source: | European Radiology. Feb2015, Vol. 25 Issue 2, p315-322. 8p. 7 Black and White Photographs, 1 Chart. |
| Subjects: | Angiosarcoma, Multiphasic health screening, Heart assist devices, Cancer, Carcinogens |
| Abstract: | Objective: To assess the imaging features of primary hepatic angiosarcoma on multiphasic CT and MR. Methods: Multi-institutional review identified 35 adults (mean age, 57.1 years; 22M/13F) with pathologically proven hepatic angiosarcoma and pretreatment multiphasic CT ( n = 33) and/or MR ( n = 7). Results: Multifocal hepatic involvement was seen in all 35 cases, with at least 10 lesions in 74.3 % (26/35). Mean size of the dominant mass was 8.9 ± 4.7 cm (range, 2.6-20 cm). Individual nodules were typically circumscribed. Arterial-phase foci of hypervascular enhancement without washout were seen in 89.7 % (26/29). Heterogeneously expanding foci of enhancement generally followed blood pool in 88.6 % (31/35). Progressive centripetal ( n = 16) or diffuse 'flash-fill' ( n = 4) enhancement pattern resembling cavernous haemangiomas predominated in 20 cases, whereas a 'reverse haemangioma' centrifugal pattern predominated in 11 cases. Rapid interval growth was seen in 24 (96.0 %) of 25 cases with serial imaging. Vascular invasion was not seen in any case. Underlying cirrhotic morphology was seen in 42.3 % (15/35). Conclusion: Primary hepatic angiosarcomas typically manifest as aggressive multifocal tumors containing small heterogeneous hypervascular foci that progressively expand and follow blood pool. The appearance can mimic cavernous haemangiomas, but distinction is generally possible. In the setting of cirrhosis, lack of tumour washout and vascular invasion argue against multifocal hepatocellular carcinoma. Key Points: • Hepatic angiosarcoma manifests on CT and MR as rapidly progressive multifocal tumours • Multiphasic imaging demonstrates hypervascular foci that progressively expand and follow blood pool • Enhancement pattern can resemble cavernous haemangiomas or show a ' reverse' centrifugal pattern • Lack of tumour washout of hypervascular lesions argues against multifocal hepatocellular carcinoma • Careful assessment of the cross- sectional imaging findings may suggest the diagnosis [ABSTRACT FROM AUTHOR] |
| Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 100372873 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Primary hepatic angiosarcoma: multi-institutional comprehensive cancer centre review of multiphasic CT and MR imaging in 35 patients. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pickhardt%2C+Perry%22">Pickhardt, Perry</searchLink><relatesTo>1</relatesTo><i> ppickhardt2@uwhealth.org</i><br /><searchLink fieldCode="AR" term="%22Kitchin%2C+Douglas%22">Kitchin, Douglas</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lubner%2C+Meghan%22">Lubner, Meghan</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ganeshan%2C+Dhakshina%22">Ganeshan, Dhakshina</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bhalla%2C+Sanjeev%22">Bhalla, Sanjeev</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Covey%2C+Anne%22">Covey, Anne</searchLink><relatesTo>4</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Feb2015, Vol. 25 Issue 2, p315-322. 8p. 7 Black and White Photographs, 1 Chart. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Angiosarcoma%22">Angiosarcoma</searchLink><br /><searchLink fieldCode="DE" term="%22Multiphasic+health+screening%22">Multiphasic health screening</searchLink><br /><searchLink fieldCode="DE" term="%22Heart+assist+devices%22">Heart assist devices</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer%22">Cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Carcinogens%22">Carcinogens</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Objective: To assess the imaging features of primary hepatic angiosarcoma on multiphasic CT and MR. Methods: Multi-institutional review identified 35 adults (mean age, 57.1 years; 22M/13F) with pathologically proven hepatic angiosarcoma and pretreatment multiphasic CT ( n = 33) and/or MR ( n = 7). Results: Multifocal hepatic involvement was seen in all 35 cases, with at least 10 lesions in 74.3 % (26/35). Mean size of the dominant mass was 8.9 ± 4.7 cm (range, 2.6-20 cm). Individual nodules were typically circumscribed. Arterial-phase foci of hypervascular enhancement without washout were seen in 89.7 % (26/29). Heterogeneously expanding foci of enhancement generally followed blood pool in 88.6 % (31/35). Progressive centripetal ( n = 16) or diffuse 'flash-fill' ( n = 4) enhancement pattern resembling cavernous haemangiomas predominated in 20 cases, whereas a 'reverse haemangioma' centrifugal pattern predominated in 11 cases. Rapid interval growth was seen in 24 (96.0 %) of 25 cases with serial imaging. Vascular invasion was not seen in any case. Underlying cirrhotic morphology was seen in 42.3 % (15/35). Conclusion: Primary hepatic angiosarcomas typically manifest as aggressive multifocal tumors containing small heterogeneous hypervascular foci that progressively expand and follow blood pool. The appearance can mimic cavernous haemangiomas, but distinction is generally possible. In the setting of cirrhosis, lack of tumour washout and vascular invasion argue against multifocal hepatocellular carcinoma. Key Points: • Hepatic angiosarcoma manifests on CT and MR as rapidly progressive multifocal tumours • Multiphasic imaging demonstrates hypervascular foci that progressively expand and follow blood pool • Enhancement pattern can resemble cavernous haemangiomas or show a ' reverse' centrifugal pattern • Lack of tumour washout of hypervascular lesions argues against multifocal hepatocellular carcinoma • Careful assessment of the cross- sectional imaging findings may suggest the diagnosis [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00330-014-3442-0 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 8 StartPage: 315 Subjects: – SubjectFull: Angiosarcoma Type: general – SubjectFull: Multiphasic health screening Type: general – SubjectFull: Heart assist devices Type: general – SubjectFull: Cancer Type: general – SubjectFull: Carcinogens Type: general Titles: – TitleFull: Primary hepatic angiosarcoma: multi-institutional comprehensive cancer centre review of multiphasic CT and MR imaging in 35 patients. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pickhardt, Perry – PersonEntity: Name: NameFull: Kitchin, Douglas – PersonEntity: Name: NameFull: Lubner, Meghan – PersonEntity: Name: NameFull: Ganeshan, Dhakshina – PersonEntity: Name: NameFull: Bhalla, Sanjeev – PersonEntity: Name: NameFull: Covey, Anne IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 02 Text: Feb2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 09387994 Numbering: – Type: volume Value: 25 – Type: issue Value: 2 Titles: – TitleFull: European Radiology Type: main |
| ResultId | 1 |
