Development of topical therapeutics for management of onychomycosis and other nail disorders: A pharmaceutical perspective.
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| Title: | Development of topical therapeutics for management of onychomycosis and other nail disorders: A pharmaceutical perspective. |
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| Authors: | Elsayed, Mustafa M.A.1 mustafa.elsayed@alexpharmres.com |
| Source: | Journal of Controlled Release. Feb2015, Vol. 199, p132-144. 13p. |
| Subjects: | Nail manifestations of general diseases, Drug development, Onychomycosis, Drug delivery systems, Disease management, Pharmaceutical research, Therapeutics |
| Abstract: | The human nail plate is a formidable barrier to drug permeation. Development of therapeutics for management of nail diseases thus remains a challenge. This article reviews the current knowledge and recent advances in the field of transungual drug delivery and provides guidance on development of topical/ungual therapeutics for management of nail diseases, with special emphasis on management of onychomycosis, the most common nail disease. Selection of drug candidates, drug delivery approaches, and evaluation of formulations are among the topics discussed. A comprehensive mathematical description for transungual permeation is also introduced. [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 100680849 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Development of topical therapeutics for management of onychomycosis and other nail disorders: A pharmaceutical perspective. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Elsayed%2C+Mustafa+M%2EA%2E%22">Elsayed, Mustafa M.A.</searchLink><relatesTo>1</relatesTo><i> mustafa.elsayed@alexpharmres.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Controlled+Release%22">Journal of Controlled Release</searchLink>. Feb2015, Vol. 199, p132-144. 13p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Nail+manifestations+of+general+diseases%22">Nail manifestations of general diseases</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+development%22">Drug development</searchLink><br /><searchLink fieldCode="DE" term="%22Onychomycosis%22">Onychomycosis</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Disease+management%22">Disease management</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+research%22">Pharmaceutical research</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: The human nail plate is a formidable barrier to drug permeation. Development of therapeutics for management of nail diseases thus remains a challenge. This article reviews the current knowledge and recent advances in the field of transungual drug delivery and provides guidance on development of topical/ungual therapeutics for management of nail diseases, with special emphasis on management of onychomycosis, the most common nail disease. Selection of drug candidates, drug delivery approaches, and evaluation of formulations are among the topics discussed. A comprehensive mathematical description for transungual permeation is also introduced. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Controlled Release is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=100680849 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jconrel.2014.11.017 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 132 Subjects: – SubjectFull: Nail manifestations of general diseases Type: general – SubjectFull: Drug development Type: general – SubjectFull: Onychomycosis Type: general – SubjectFull: Drug delivery systems Type: general – SubjectFull: Disease management Type: general – SubjectFull: Pharmaceutical research Type: general – SubjectFull: Therapeutics Type: general Titles: – TitleFull: Development of topical therapeutics for management of onychomycosis and other nail disorders: A pharmaceutical perspective. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Elsayed, Mustafa M.A. IsPartOfRelationships: – BibEntity: Dates: – D: 10 M: 02 Text: Feb2015 Type: published Y: 2015 Identifiers: – Type: issn-print Value: 01683659 Numbering: – Type: volume Value: 199 Titles: – TitleFull: Journal of Controlled Release Type: main |
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