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The future of the patient-specific Body-on-a-chip.

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Title: The future of the patient-specific Body-on-a-chip.
Authors: Williamson, Adam1, Singh, Sukhdeep1, Fernekorn, Uta1, Schober, Andreas1
Source: Lab on a Chip. 2013, Vol. 13 Issue 18, p3471-3480. 10p.
Subjects: Induced pluripotent stem cells, Artificial livers, Cell culture, Kidneys, Lungs
Abstract: As significant advancements in technology focused on Organ-on-a-chip continue, it is feasible to consider the future of Body-on-a-chip technology. With serious work being done to realize functioning artificial livers, kidneys, hearts, and lungs on chips, the next step is not only to interconnect these organs but also to consider the integration of stem cell technology to create interconnected patient-specific organs. Such a patient-specific Body-on-a-chip requires a sophisticated set of tools for micropattering cell cultures in 3D to create interconnected tissue-like organ structures. This review discusses advanced methods of the past two years in on-Chip organs, the complex 3D patterning of cultures and state-of-the-art scaffolding, and discusses some of the most relevant advancements in human-induced pluripotent stem cell (hiPSC) research applied to these organs and scaffolds for the future of a patient-specific Body-on-a-chip. We anticipate that such a technology would have a wide area of application, primarily benefiting drug development, chemical safety testing, and disease modeling. [ABSTRACT FROM AUTHOR]
Copyright of Lab on a Chip is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
An: 100894158
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PubType: Academic Journal
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  Data: <searchLink fieldCode="AR" term="%22Williamson%2C+Adam%22">Williamson, Adam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Singh%2C+Sukhdeep%22">Singh, Sukhdeep</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fernekorn%2C+Uta%22">Fernekorn, Uta</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Schober%2C+Andreas%22">Schober, Andreas</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Lab+on+a+Chip%22">Lab on a Chip</searchLink>. 2013, Vol. 13 Issue 18, p3471-3480. 10p.
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  Data: <searchLink fieldCode="DE" term="%22Induced+pluripotent+stem+cells%22">Induced pluripotent stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Artificial+livers%22">Artificial livers</searchLink><br /><searchLink fieldCode="DE" term="%22Cell+culture%22">Cell culture</searchLink><br /><searchLink fieldCode="DE" term="%22Kidneys%22">Kidneys</searchLink><br /><searchLink fieldCode="DE" term="%22Lungs%22">Lungs</searchLink>
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  Data: As significant advancements in technology focused on Organ-on-a-chip continue, it is feasible to consider the future of Body-on-a-chip technology. With serious work being done to realize functioning artificial livers, kidneys, hearts, and lungs on chips, the next step is not only to interconnect these organs but also to consider the integration of stem cell technology to create interconnected patient-specific organs. Such a patient-specific Body-on-a-chip requires a sophisticated set of tools for micropattering cell cultures in 3D to create interconnected tissue-like organ structures. This review discusses advanced methods of the past two years in on-Chip organs, the complex 3D patterning of cultures and state-of-the-art scaffolding, and discusses some of the most relevant advancements in human-induced pluripotent stem cell (hiPSC) research applied to these organs and scaffolds for the future of a patient-specific Body-on-a-chip. We anticipate that such a technology would have a wide area of application, primarily benefiting drug development, chemical safety testing, and disease modeling. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Lab on a Chip is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1039/c3lc50237f
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        Text: English
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        Type: general
      – SubjectFull: Artificial livers
        Type: general
      – SubjectFull: Cell culture
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      – SubjectFull: Kidneys
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      – SubjectFull: Lungs
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              Text: 2013
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