View in EDS PDF Full Text

Intraindividual, randomized comparison of the macrocyclic contrast agents gadobutrol and gadoterate meglumine in breast magnetic resonance imaging.

Saved in:
Bibliographic Details
Title: Intraindividual, randomized comparison of the macrocyclic contrast agents gadobutrol and gadoterate meglumine in breast magnetic resonance imaging.
Authors: Fallenberg, Eva1 eva.fallenberg@charite.de, Renz, Diane1, Karle, Bettina2, Schwenke, Carsten3, Ingod-Heppner, Barbara4, Reles, Angela5, Engelken, Florian6, Huppertz, Alexander7, Hamm, Bernd1, Taupitz, Matthias7
Source: European Radiology. Mar2015, Vol. 25 Issue 3, p837-849. 13p.
Subjects: Magnetic resonance imaging, Breast cancer diagnosis, Tissue wounds, Diagnostic imaging research, Medical imaging systems
Abstract: Objectives: To compare intraindividually two macrocyclic contrast agents - gadobutrol and gadoterate meglumine (Gd-DOTA) - for dynamic and quantitative assessment of relative enhancement (RE) in benign and malignant breast lesions. Methods: This was an ethically approved, prospective, single-centre, randomized, crossover study in 52 women with suspected breast lesions referred for magnetic resonance imaging (MRI). Each patient underwent one examination with gadobutrol and one with Gd-DOTA (0.1 mmol/kg BW) on a 1.5 T system 1 - 7 days apart. Dynamic, T1-weighted, 3D gradient echo sequences were acquired under identical conditions. Quantitative evaluation with at least three regions of interest (ROI) per lesion was performed. Primary endpoint was RE during the initial postcontrast phase after the first and second dynamic acquisition, and peak RE. All lesions were histologically proven; differences between the examinations were evaluated. Results: Forty-five patients with a total of 11 benign and 34 malignant lesions were assessed. Mean RE was significantly higher for gadobutrol than Gd-DOTA ( p < 0.0001). Gadobutrol showed significantly less washout (64.4 %) than Gd-DOTA (75.4 %) in malignant lesions ( p = 0.048) Conclusions: Gadobutrol has higher RE values compared with Gd-DOTA, whereas Gd-DOTA shows more marked washout in malignant lesions. This might improve the detection of breast lesions and influence the specificity of breast MRI-imaging. Key Points: • Contrast agents differ in terms of peak enhancement and postinitial contrast behaviour. • Gadobutrol results in greater peak RE in lesions, likely due to relaxivity. • Gd-DOTA shows more pronounced washout in postinitial contrast behaviour of malignant lesions. • Further investigations of the differences among GD-CM may improve sensitivity and specificity. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: egs
DbLabel: Engineering Source
An: 100989890
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Intraindividual, randomized comparison of the macrocyclic contrast agents gadobutrol and gadoterate meglumine in breast magnetic resonance imaging.
– Name: Author
  Label: Authors
  Group: Au
  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Fallenberg%2C+Eva%22&quot;&gt;Fallenberg, Eva&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;i&gt; eva.fallenberg@charite.de&lt;/i&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Renz%2C+Diane%22&quot;&gt;Renz, Diane&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Karle%2C+Bettina%22&quot;&gt;Karle, Bettina&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Schwenke%2C+Carsten%22&quot;&gt;Schwenke, Carsten&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Ingod-Heppner%2C+Barbara%22&quot;&gt;Ingod-Heppner, Barbara&lt;/searchLink&gt;&lt;relatesTo&gt;4&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Reles%2C+Angela%22&quot;&gt;Reles, Angela&lt;/searchLink&gt;&lt;relatesTo&gt;5&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Engelken%2C+Florian%22&quot;&gt;Engelken, Florian&lt;/searchLink&gt;&lt;relatesTo&gt;6&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Huppertz%2C+Alexander%22&quot;&gt;Huppertz, Alexander&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hamm%2C+Bernd%22&quot;&gt;Hamm, Bernd&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Taupitz%2C+Matthias%22&quot;&gt;Taupitz, Matthias&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt;
– Name: TitleSource
  Label: Source
  Group: Src
  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Mar2015, Vol. 25 Issue 3, p837-849. 13p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: &lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Magnetic+resonance+imaging%22&quot;&gt;Magnetic resonance imaging&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Breast+cancer+diagnosis%22&quot;&gt;Breast cancer diagnosis&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Tissue+wounds%22&quot;&gt;Tissue wounds&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Diagnostic+imaging+research%22&quot;&gt;Diagnostic imaging research&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Medical+imaging+systems%22&quot;&gt;Medical imaging systems&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Objectives: To compare intraindividually two macrocyclic contrast agents - gadobutrol and gadoterate meglumine (Gd-DOTA) - for dynamic and quantitative assessment of relative enhancement (RE) in benign and malignant breast lesions. Methods: This was an ethically approved, prospective, single-centre, randomized, crossover study in 52 women with suspected breast lesions referred for magnetic resonance imaging (MRI). Each patient underwent one examination with gadobutrol and one with Gd-DOTA (0.1 mmol/kg BW) on a 1.5 T system 1 - 7 days apart. Dynamic, T1-weighted, 3D gradient echo sequences were acquired under identical conditions. Quantitative evaluation with at least three regions of interest (ROI) per lesion was performed. Primary endpoint was RE during the initial postcontrast phase after the first and second dynamic acquisition, and peak RE. All lesions were histologically proven; differences between the examinations were evaluated. Results: Forty-five patients with a total of 11 benign and 34 malignant lesions were assessed. Mean RE was significantly higher for gadobutrol than Gd-DOTA ( p &lt; 0.0001). Gadobutrol showed significantly less washout (64.4 %) than Gd-DOTA (75.4 %) in malignant lesions ( p = 0.048) Conclusions: Gadobutrol has higher RE values compared with Gd-DOTA, whereas Gd-DOTA shows more marked washout in malignant lesions. This might improve the detection of breast lesions and influence the specificity of breast MRI-imaging. Key Points: • Contrast agents differ in terms of peak enhancement and postinitial contrast behaviour. • Gadobutrol results in greater peak RE in lesions, likely due to relaxivity. • Gd-DOTA shows more pronounced washout in postinitial contrast behaviour of malignant lesions. • Further investigations of the differences among GD-CM may improve sensitivity and specificity. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=100989890
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1007/s00330-014-3426-0
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 837
    Subjects:
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Breast cancer diagnosis
        Type: general
      – SubjectFull: Tissue wounds
        Type: general
      – SubjectFull: Diagnostic imaging research
        Type: general
      – SubjectFull: Medical imaging systems
        Type: general
    Titles:
      – TitleFull: Intraindividual, randomized comparison of the macrocyclic contrast agents gadobutrol and gadoterate meglumine in breast magnetic resonance imaging.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Fallenberg, Eva
      – PersonEntity:
          Name:
            NameFull: Renz, Diane
      – PersonEntity:
          Name:
            NameFull: Karle, Bettina
      – PersonEntity:
          Name:
            NameFull: Schwenke, Carsten
      – PersonEntity:
          Name:
            NameFull: Ingod-Heppner, Barbara
      – PersonEntity:
          Name:
            NameFull: Reles, Angela
      – PersonEntity:
          Name:
            NameFull: Engelken, Florian
      – PersonEntity:
          Name:
            NameFull: Huppertz, Alexander
      – PersonEntity:
          Name:
            NameFull: Hamm, Bernd
      – PersonEntity:
          Name:
            NameFull: Taupitz, Matthias
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 03
              Text: Mar2015
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-print
              Value: 09387994
          Numbering:
            – Type: volume
              Value: 25
            – Type: issue
              Value: 3
          Titles:
            – TitleFull: European Radiology
              Type: main
ResultId 1