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Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair.

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Title: Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair.
Authors: Pateman, Christopher J.1, Harding, Adam J.2, Glen, Adam1, Taylor, Caroline S.1, Christmas, Claire R.2, Robinson, Peter P.2, Rimmer, Steve3, Boissonade, Fiona M.2 f.boissonade@sheffield.ac.uk, Claeyssens, Frederik1 f.claeyssens@sheffield.ac.uk, Haycock, John W.1 j.w.haycock@sheffield.ac.uk
Source: Biomaterials. May2015, Vol. 49, p77-89. 13p.
Subjects: Peripheral nerve injuries, Medical polymers, Phototherapy, Autografts, Polyethylene glycol, Tissue engineering, Therapeutics
Abstract: The peripheral nervous system has a limited innate capacity for self-repair following injury, and surgical intervention is often required. For injuries greater than a few millimeters autografting is standard practice although it is associated with donor site morbidity and is limited in its availability. Because of this, nerve guidance conduits (NGCs) can be viewed as an advantageous alternative, but currently have limited efficacy for short and large injury gaps in comparison to autograft. Current commercially available NGC designs rely on existing regulatory approved materials and traditional production methods, limiting improvement of their design. The aim of this study was to establish a novel method for NGC manufacture using a custom built laser-based microstereolithography (μSL) setup that incorporated a 405 nm laser source to produce 3D constructs with ∼50 μm resolution from a photocurable poly(ethylene glycol) resin. These were evaluated by SEM, in vitro neuronal, Schwann and dorsal root ganglion culture and in vivo using a thy-1-YFP-H mouse common fibular nerve injury model. NGCs with dimensions of 1 mm internal diameter × 5 mm length with a wall thickness of 250 μm were fabricated and capable of supporting re-innervation across a 3 mm injury gap after 21 days, with results close to that of an autograft control. The study provides a technology platform for the rapid microfabrication of biocompatible materials, a novel method for in vivo evaluation, and a benchmark for future development in more advanced NGC designs, biodegradable and larger device sizes, and longer-term implantation studies. [ABSTRACT FROM AUTHOR]
Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair.
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  Data: <searchLink fieldCode="AR" term="%22Pateman%2C+Christopher+J%2E%22">Pateman, Christopher J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Harding%2C+Adam+J%2E%22">Harding, Adam J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Glen%2C+Adam%22">Glen, Adam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Taylor%2C+Caroline+S%2E%22">Taylor, Caroline S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Christmas%2C+Claire+R%2E%22">Christmas, Claire R.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Robinson%2C+Peter+P%2E%22">Robinson, Peter P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Rimmer%2C+Steve%22">Rimmer, Steve</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Boissonade%2C+Fiona+M%2E%22">Boissonade, Fiona M.</searchLink><relatesTo>2</relatesTo><i> f.boissonade@sheffield.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Claeyssens%2C+Frederik%22">Claeyssens, Frederik</searchLink><relatesTo>1</relatesTo><i> f.claeyssens@sheffield.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Haycock%2C+John+W%2E%22">Haycock, John W.</searchLink><relatesTo>1</relatesTo><i> j.w.haycock@sheffield.ac.uk</i>
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  Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. May2015, Vol. 49, p77-89. 13p.
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  Data: <searchLink fieldCode="DE" term="%22Peripheral+nerve+injuries%22">Peripheral nerve injuries</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+polymers%22">Medical polymers</searchLink><br /><searchLink fieldCode="DE" term="%22Phototherapy%22">Phototherapy</searchLink><br /><searchLink fieldCode="DE" term="%22Autografts%22">Autografts</searchLink><br /><searchLink fieldCode="DE" term="%22Polyethylene+glycol%22">Polyethylene glycol</searchLink><br /><searchLink fieldCode="DE" term="%22Tissue+engineering%22">Tissue engineering</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink>
– Name: Abstract
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  Data: The peripheral nervous system has a limited innate capacity for self-repair following injury, and surgical intervention is often required. For injuries greater than a few millimeters autografting is standard practice although it is associated with donor site morbidity and is limited in its availability. Because of this, nerve guidance conduits (NGCs) can be viewed as an advantageous alternative, but currently have limited efficacy for short and large injury gaps in comparison to autograft. Current commercially available NGC designs rely on existing regulatory approved materials and traditional production methods, limiting improvement of their design. The aim of this study was to establish a novel method for NGC manufacture using a custom built laser-based microstereolithography (μSL) setup that incorporated a 405 nm laser source to produce 3D constructs with ∼50 μm resolution from a photocurable poly(ethylene glycol) resin. These were evaluated by SEM, in vitro neuronal, Schwann and dorsal root ganglion culture and in vivo using a thy-1-YFP-H mouse common fibular nerve injury model. NGCs with dimensions of 1 mm internal diameter × 5 mm length with a wall thickness of 250 μm were fabricated and capable of supporting re-innervation across a 3 mm injury gap after 21 days, with results close to that of an autograft control. The study provides a technology platform for the rapid microfabrication of biocompatible materials, a novel method for in vivo evaluation, and a benchmark for future development in more advanced NGC designs, biodegradable and larger device sizes, and longer-term implantation studies. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.biomaterials.2015.01.055
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      – Code: eng
        Text: English
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        PageCount: 13
        StartPage: 77
    Subjects:
      – SubjectFull: Peripheral nerve injuries
        Type: general
      – SubjectFull: Medical polymers
        Type: general
      – SubjectFull: Phototherapy
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      – SubjectFull: Autografts
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      – SubjectFull: Polyethylene glycol
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      – SubjectFull: Tissue engineering
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      – SubjectFull: Therapeutics
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      – TitleFull: Nerve guides manufactured from photocurable polymers to aid peripheral nerve repair.
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              Text: May2015
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