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Imaging-based evaluation of liver function: comparison of Tc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI.

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Title: Imaging-based evaluation of liver function: comparison of Tc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI.
Authors: Geisel, Dominik1 dominik.geisel@charite.de, Lüdemann, Lutz2, Fröling, Vera, Malinowski, Maciej3, Stockmann, Martin3, Baron, Annekathrin3, Gebauer, Bernhard1, Seehofer, Daniel3, Prasad, Vikas4, Denecke, Timm
Source: European Radiology. May2015, Vol. 25 Issue 5, p1384-1391. 8p.
Subjects: Magnetic resonance imaging, Liver function tests, Positron emission tomography, Liver disease diagnosis, Diagnostic imaging
Abstract: Objectives: To compare Gd-EOB-enhanced MRI and Tc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function. Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and Tc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T, T and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL. Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL ( r = 0.802, p = 0.001) and RE for LLL ( r = 0.704, p = 0.005) and moderate correlation with HUI for LLL ( r = 0.560, p = 0.037) and RE for RLL ( r = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation ( r = 0.775, p = 0.002). Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and Tc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function. Key points: • Information about liver function can be acquired with routine Gd- EOB- MRI. • Gd- EOB- MRI and Tc- mebrofenin HBS show elevated function of non- embolized lobe. • Gd- EOB- MRI and Tc- mebrofenin HBS can determine lobar liver function. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Imaging-based evaluation of liver function: comparison of Tc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI.
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  Data: <searchLink fieldCode="AR" term="%22Geisel%2C+Dominik%22">Geisel, Dominik</searchLink><relatesTo>1</relatesTo><i> dominik.geisel@charite.de</i><br /><searchLink fieldCode="AR" term="%22Lüdemann%2C+Lutz%22">Lüdemann, Lutz</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Fröling%2C+Vera%22">Fröling, Vera</searchLink><br /><searchLink fieldCode="AR" term="%22Malinowski%2C+Maciej%22">Malinowski, Maciej</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Stockmann%2C+Martin%22">Stockmann, Martin</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Baron%2C+Annekathrin%22">Baron, Annekathrin</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Gebauer%2C+Bernhard%22">Gebauer, Bernhard</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Seehofer%2C+Daniel%22">Seehofer, Daniel</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Prasad%2C+Vikas%22">Prasad, Vikas</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Denecke%2C+Timm%22">Denecke, Timm</searchLink>
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. May2015, Vol. 25 Issue 5, p1384-1391. 8p.
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  Data: Objectives: To compare Gd-EOB-enhanced MRI and Tc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function. Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and Tc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T, T and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL. Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL ( r = 0.802, p = 0.001) and RE for LLL ( r = 0.704, p = 0.005) and moderate correlation with HUI for LLL ( r = 0.560, p = 0.037) and RE for RLL ( r = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation ( r = 0.775, p = 0.002). Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and Tc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function. Key points: • Information about liver function can be acquired with routine Gd- EOB- MRI. • Gd- EOB- MRI and Tc- mebrofenin HBS show elevated function of non- embolized lobe. • Gd- EOB- MRI and Tc- mebrofenin HBS can determine lobar liver function. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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