Imaging-based evaluation of liver function: comparison of Tc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI.
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| Title: | Imaging-based evaluation of liver function: comparison of Tc-mebrofenin hepatobiliary scintigraphy and Gd-EOB-DTPA-enhanced MRI. |
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| Authors: | Geisel, Dominik1 dominik.geisel@charite.de, Lüdemann, Lutz2, Fröling, Vera, Malinowski, Maciej3, Stockmann, Martin3, Baron, Annekathrin3, Gebauer, Bernhard1, Seehofer, Daniel3, Prasad, Vikas4, Denecke, Timm |
| Source: | European Radiology. May2015, Vol. 25 Issue 5, p1384-1391. 8p. |
| Subjects: | Magnetic resonance imaging, Liver function tests, Positron emission tomography, Liver disease diagnosis, Diagnostic imaging |
| Abstract: | Objectives: To compare Gd-EOB-enhanced MRI and Tc-mebrofenin hepatobiliary scintigraphy (HBS) as imaging-based liver function tests for separate evaluation of right (RLL) and left liver lobe (LLL) function. Methods: Fourteen patients underwent Gd-EOB-enhanced MRI and Tc-mebrofenin HBS after portal vein embolization within 24 h. Relative enhancement (RE) and hepatic uptake index (HUI) were determined from MRI; and T, T and mebrofenin uptake were determined from HBS, all values separately for RLL and LLL. Results: Mebrofenin uptake correlated significantly with HUI and RE for both liver lobes. There was strong correlation of mebrofenin uptake with HUI for RLL ( r = 0.802, p = 0.001) and RE for LLL ( r = 0.704, p = 0.005) and moderate correlation with HUI for LLL ( r = 0.560, p = 0.037) and RE for RLL ( r = 0.620, p = 0.018). Correlating the percentage share of RLL function derived from MRI (with HUI) with the percentage of RLL function derived from mebrofenin uptake revealed a strong correlation ( r = 0.775, p = 0.002). Conclusions: Both RE and HUI correlate with mebrofenin uptake in HBS. The results suggest that Gd-EOB-enhanced MRI and Tc-mebrofenin HBS may equally be used to separately determine right and left liver lobe function. Key points: • Information about liver function can be acquired with routine Gd- EOB- MRI. • Gd- EOB- MRI and Tc- mebrofenin HBS show elevated function of non- embolized lobe. • Gd- EOB- MRI and Tc- mebrofenin HBS can determine lobar liver function. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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