Preparation of Pure PLLA, Pure Chitosan, and PLLA/Chitosan Blend Porous Tissue Engineering Scaffolds by Thermally Induced Phase Separation Method and Evaluation of the Corresponding Mechanical and Biological Properties.
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| Title: | Preparation of Pure PLLA, Pure Chitosan, and PLLA/Chitosan Blend Porous Tissue Engineering Scaffolds by Thermally Induced Phase Separation Method and Evaluation of the Corresponding Mechanical and Biological Properties. |
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| Authors: | Salehi, Majid1 (AUTHOR), Naseri Nosar, Mahdi2 (AUTHOR), Amani, Amir1 (AUTHOR), Azami, Mahmoud1 (AUTHOR), Tavakol, Shima1 (AUTHOR), Ghanbari, Hossein1 (AUTHOR) hghanbari@tums.ac.ir |
| Source: | International Journal of Polymeric Materials & Polymeric Biomaterials. 2015, Vol. 64 Issue 13, p675-682. 8p. |
| Subjects: | Chitosan, Phase separation method (Engineering), Lactic acid, Tissue engineering, Porous materials, Tissue scaffolds |
| Abstract: | The aim of this work was to prepare the scaffolds of pure poly (L-lactic acid) 3% (w/v), pure chitosan 3% (w/v), and PLLA/chitosan blend (1:5) 3% (w/v) using TIPS method and investigate their properties and application in tissue engineering. An in vitro degradation study of scaffolds showed the addition of chitosan to PLLA not only increased its degradation rate, but also slowed down its pH value reduction. Addition of chitosan to PLLA increased hydrophilicity, porosity, compressive properties, and cell viability of the scaffolds. The results indicate that among all scaffolds, the most appropriate candidate for tissue engineering is PLLA/chitosan blend. [ABSTRACT FROM PUBLISHER] |
| Copyright of International Journal of Polymeric Materials & Polymeric Biomaterials is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Abstract: | The aim of this work was to prepare the scaffolds of pure poly (L-lactic acid) 3% (w/v), pure chitosan 3% (w/v), and PLLA/chitosan blend (1:5) 3% (w/v) using TIPS method and investigate their properties and application in tissue engineering. An in vitro degradation study of scaffolds showed the addition of chitosan to PLLA not only increased its degradation rate, but also slowed down its pH value reduction. Addition of chitosan to PLLA increased hydrophilicity, porosity, compressive properties, and cell viability of the scaffolds. The results indicate that among all scaffolds, the most appropriate candidate for tissue engineering is PLLA/chitosan blend. [ABSTRACT FROM PUBLISHER] |
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| ISSN: | 00914037 |
| DOI: | 10.1080/00914037.2014.1002093 |
