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Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents.

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Title: Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents.
Authors: Cavalli, R.1 roberta.cavalli@unito.it, Argenziano, M.1, Vigna, E.1, Giustetto, P.2, Torres, E.2, Aime, S.2, Terreno, E.2 enzo.terreno@unito.it
Source: Colloids & Surfaces B: Biointerfaces. May2015, Vol. 129, p39-46. 8p.
Subjects: In vitro studies, Magnetic resonance imaging, Prednisolone, Diagnostic imaging, Aqueous solutions, Ultrasonic imaging
Abstract: Theranostic delivery systems are nanostructures that combine the modality of therapy and diagnostic imaging. Polymeric micro- and nanobubbles, spherical vesicles containing a gas core, have been proposed as new theranostic carriers for MRI-guided therapy. In this study, chitosan nanobubbles were purposely tuned for the co-delivery of prednisolone phosphate and a Gd(III) complex, as therapeutic and MRI diagnostic agent, respectively. Perfluoropentane was used for filling up the internal core of the formulation. These theranostic nanobubbles showed diameters of about 500 nm and a positive surface charge that allows the interaction with the negatively charged Gd-DOTP complex. Pluronic F68 was added to the nanobubble aqueous suspension as stabilizer agent. The encapsulation efficiency was good for both the active compounds, and a prolonged drug release profile was observed in vitro . The effect of ultrasound stimulation on prednisolone phosphate release was evaluated at 37 °C. A marked increase on drug release kinetics with no burst effect was obtained after the exposure of the system to ultrasound. Furthermore, the relaxivity of the MRI probe changed upon incorporation in the nanobubble shell, thereby offering interesting opportunity in dual MRI-US experiments. The ultrasound characterization showed a good in vitro echogenicity of the theranostic nanobubbles. In summary, chitosan drug-loaded nanobubbles with Gd(III) complex bound to their shell might be considered a new platform for imaging and drug delivery with the potential of improving anti-cancer treatments. [ABSTRACT FROM AUTHOR]
Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 102494089
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents.
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  Data: <searchLink fieldCode="AR" term="%22Cavalli%2C+R%2E%22">Cavalli, R.</searchLink><relatesTo>1</relatesTo><i> roberta.cavalli@unito.it</i><br /><searchLink fieldCode="AR" term="%22Argenziano%2C+M%2E%22">Argenziano, M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vigna%2C+E%2E%22">Vigna, E.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Giustetto%2C+P%2E%22">Giustetto, P.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Torres%2C+E%2E%22">Torres, E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Aime%2C+S%2E%22">Aime, S.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Terreno%2C+E%2E%22">Terreno, E.</searchLink><relatesTo>2</relatesTo><i> enzo.terreno@unito.it</i>
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  Data: <searchLink fieldCode="JN" term="%22Colloids+%26+Surfaces+B%3A+Biointerfaces%22">Colloids & Surfaces B: Biointerfaces</searchLink>. May2015, Vol. 129, p39-46. 8p.
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  Data: <searchLink fieldCode="DE" term="%22In+vitro+studies%22">In vitro studies</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Prednisolone%22">Prednisolone</searchLink><br /><searchLink fieldCode="DE" term="%22Diagnostic+imaging%22">Diagnostic imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Aqueous+solutions%22">Aqueous solutions</searchLink><br /><searchLink fieldCode="DE" term="%22Ultrasonic+imaging%22">Ultrasonic imaging</searchLink>
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  Data: Theranostic delivery systems are nanostructures that combine the modality of therapy and diagnostic imaging. Polymeric micro- and nanobubbles, spherical vesicles containing a gas core, have been proposed as new theranostic carriers for MRI-guided therapy. In this study, chitosan nanobubbles were purposely tuned for the co-delivery of prednisolone phosphate and a Gd(III) complex, as therapeutic and MRI diagnostic agent, respectively. Perfluoropentane was used for filling up the internal core of the formulation. These theranostic nanobubbles showed diameters of about 500 nm and a positive surface charge that allows the interaction with the negatively charged Gd-DOTP complex. Pluronic F68 was added to the nanobubble aqueous suspension as stabilizer agent. The encapsulation efficiency was good for both the active compounds, and a prolonged drug release profile was observed in vitro . The effect of ultrasound stimulation on prednisolone phosphate release was evaluated at 37 °C. A marked increase on drug release kinetics with no burst effect was obtained after the exposure of the system to ultrasound. Furthermore, the relaxivity of the MRI probe changed upon incorporation in the nanobubble shell, thereby offering interesting opportunity in dual MRI-US experiments. The ultrasound characterization showed a good in vitro echogenicity of the theranostic nanobubbles. In summary, chitosan drug-loaded nanobubbles with Gd(III) complex bound to their shell might be considered a new platform for imaging and drug delivery with the potential of improving anti-cancer treatments. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Colloids & Surfaces B: Biointerfaces is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
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        Value: 10.1016/j.colsurfb.2015.03.023
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      – Code: eng
        Text: English
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        PageCount: 8
        StartPage: 39
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      – SubjectFull: In vitro studies
        Type: general
      – SubjectFull: Magnetic resonance imaging
        Type: general
      – SubjectFull: Prednisolone
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      – SubjectFull: Diagnostic imaging
        Type: general
      – SubjectFull: Aqueous solutions
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      – SubjectFull: Ultrasonic imaging
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      – TitleFull: Preparation and in vitro characterization of chitosan nanobubbles as theranostic agents.
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            – D: 01
              M: 05
              Text: May2015
              Type: published
              Y: 2015
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