On treatment of tuberculosis in heterogeneous populations
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| Title: | On treatment of tuberculosis in heterogeneous populations |
|---|---|
| Authors: | Murphy, Brian M.1, Singer, Benjamin H.1, Kirschner, Denise kirschne@umich.edu |
| Source: | Journal of Theoretical Biology. Aug2003, Vol. 223 Issue 4, p391. 14p. |
| Subjects: | Tuberculosis treatment, Demography |
| Abstract: | Global eradication of tuberculosis (TB) is an international agenda. Thus understanding effects of treatment of TB in different settings is crucial. In previous work, we introduced the framework for a mathematical model of epidemic TB in demographically distinct, heterogeneous populations. Simulations showed the importance of genetic susceptibility in determining endemic prevalence levels. In the work presented here, we include treatment and investigate different strategies for treatment of latent and active TB disease in heterogeneous populations. We illustrate how the presence of a genetically susceptible subpopulation dramatically alters effects of treatment in the same way a core population does in the setting of sexually transmitted diseases. In addition, we evaluate treatment strategies that focus specifically on this subpopulation, and our results indicate that genetically susceptible subpopulations should be accounted for when designing treatment strategies to achieve the greatest reduction in disease prevalence. [Copyright &y& Elsevier] |
| Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 10318868 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: On treatment of tuberculosis in heterogeneous populations – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Murphy%2C+Brian+M%2E%22">Murphy, Brian M.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Singer%2C+Benjamin+H%2E%22">Singer, Benjamin H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kirschner%2C+Denise%22">Kirschner, Denise</searchLink><i> kirschne@umich.edu</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Theoretical+Biology%22">Journal of Theoretical Biology</searchLink>. Aug2003, Vol. 223 Issue 4, p391. 14p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Tuberculosis+treatment%22">Tuberculosis treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Demography%22">Demography</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Global eradication of tuberculosis (TB) is an international agenda. Thus understanding effects of treatment of TB in different settings is crucial. In previous work, we introduced the framework for a mathematical model of epidemic TB in demographically distinct, heterogeneous populations. Simulations showed the importance of genetic susceptibility in determining endemic prevalence levels. In the work presented here, we include treatment and investigate different strategies for treatment of latent and active TB disease in heterogeneous populations. We illustrate how the presence of a genetically susceptible subpopulation dramatically alters effects of treatment in the same way a core population does in the setting of sexually transmitted diseases. In addition, we evaluate treatment strategies that focus specifically on this subpopulation, and our results indicate that genetically susceptible subpopulations should be accounted for when designing treatment strategies to achieve the greatest reduction in disease prevalence. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Theoretical Biology is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=10318868 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/S0022-5193(03)00038-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 391 Subjects: – SubjectFull: Tuberculosis treatment Type: general – SubjectFull: Demography Type: general Titles: – TitleFull: On treatment of tuberculosis in heterogeneous populations Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Murphy, Brian M. – PersonEntity: Name: NameFull: Singer, Benjamin H. – PersonEntity: Name: NameFull: Kirschner, Denise IsPartOfRelationships: – BibEntity: Dates: – D: 21 M: 08 Text: Aug2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00225193 Numbering: – Type: volume Value: 223 – Type: issue Value: 4 Titles: – TitleFull: Journal of Theoretical Biology Type: main |
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