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Ruthenium(II) acetylacetonato–sulfoxide complexes

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Title: Ruthenium(II) acetylacetonato–sulfoxide complexes
Authors: Wu, Adam1, Kennedy, David C.1, Patrick, Brian O.1, James, Brian R. brj@chem.ubc.ca
Source: Inorganic Chemistry Communications. Aug2003, Vol. 6 Issue 8, p996. 5p.
Subjects: Nuclear magnetic resonance spectroscopy, Ruthenium
Abstract: The water-soluble RuII acetylacetonato–sulfoxide complexes, cis-Ru(acac)2(DMSO)2 (1) and Ru(acac)2(meso-BESE) (2), were synthesized (BESE=1,2-bis(ethylsulfinyl)ethane=EtS(O)(CH2)2S(O)Et). Both complexes were characterized by 1H and 13C{1H} NMR, UV–Vis, and IR spectroscopies, as well as MS, elemental analysis, solution conductivity, and cyclic voltammetry, while the molecular structure of 2 was determined also by X-ray crystallography. All sulfoxide ligands are S-bonded. The complexes were tested against human breast cancer cells (MDA-MB-435S) using an in vitro MTT assay, a colorimetric determination of cell viability; IC50 values of >2000 and 1500 ± 100 μM were determined for 1 and 2, respectively, while cisplatin exhibits an IC50 value of 30 ± 5 μM. [Copyright &y& Elsevier]
Copyright of Inorganic Chemistry Communications is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Ruthenium(II) acetylacetonato–sulfoxide complexes
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  Data: <searchLink fieldCode="AR" term="%22Wu%2C+Adam%22">Wu, Adam</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kennedy%2C+David+C%2E%22">Kennedy, David C.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Patrick%2C+Brian+O%2E%22">Patrick, Brian O.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22James%2C+Brian+R%2E%22">James, Brian R.</searchLink><i> brj@chem.ubc.ca</i>
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  Data: <searchLink fieldCode="JN" term="%22Inorganic+Chemistry+Communications%22">Inorganic Chemistry Communications</searchLink>. Aug2003, Vol. 6 Issue 8, p996. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance+spectroscopy%22">Nuclear magnetic resonance spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22Ruthenium%22">Ruthenium</searchLink>
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  Label: Abstract
  Group: Ab
  Data: The water-soluble RuII acetylacetonato–sulfoxide complexes, cis-Ru(acac)2(DMSO)2 (1) and Ru(acac)2(meso-BESE) (2), were synthesized (BESE=1,2-bis(ethylsulfinyl)ethane=EtS(O)(CH2)2S(O)Et). Both complexes were characterized by 1H and 13C{1H} NMR, UV–Vis, and IR spectroscopies, as well as MS, elemental analysis, solution conductivity, and cyclic voltammetry, while the molecular structure of 2 was determined also by X-ray crystallography. All sulfoxide ligands are S-bonded. The complexes were tested against human breast cancer cells (MDA-MB-435S) using an in vitro MTT assay, a colorimetric determination of cell viability; IC50 values of <f>></f>2000 and 1500 ± 100 μM were determined for 1 and 2, respectively, while cisplatin exhibits an IC50 value of 30 ± 5 μM. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Inorganic Chemistry Communications is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/S1387-7003(03)00164-3
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        Text: English
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      – SubjectFull: Ruthenium
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      – TitleFull: Ruthenium(II) acetylacetonato–sulfoxide complexes
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              Text: Aug2003
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              Y: 2003
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