Improved Dynamic Response Assessment for Intra-Articular Injected Iron Oxide Nanoparticles.
Saved in:
| Title: | Improved Dynamic Response Assessment for Intra-Articular Injected Iron Oxide Nanoparticles. |
|---|---|
| Authors: | Crowe, L. A.1 lindsey.crowe@hcuge.ch, Tobalem, F.1, Gramoun, A.1, Delattre, B. M. A.1, Grosdemange, K.1, Salaklang, J.2, Redjem, A.2, Petri-Fink, A.2, Hofmann, H.3, Vallée, J. -P.1 |
| Source: | Magnetic Resonance in Medicine. Nov2012, Vol. 68 Issue 5, p1544-1552. 9p. |
| Abstract: | The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss measurements of iron oxide nanoparticle containing tissues saturate at medium concentrations and show a nonlinear/nonproportional intensity to concentration profile due to the competing effects of T1 and T2 relaxation. A concentration calibration phantom and an in vivo study of intra-articular injection in a rat knee of known concentrations of iron oxide were assessed using the difference-ultrashort echo time sequence giving a positive, quantifiable, unambiguous iron signal and monotonic, increasing concentration response over a wide concentration range in the phantom with limited susceptibility artifacts and high contrast in vivo to all other tissues. This improved dynamic response to concentration opens possibilities for quantification due to its linear nature at physiologically relevant concentrations. [ABSTRACT FROM AUTHOR] |
| Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: egs DbLabel: Engineering Source An: 103682843 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Improved Dynamic Response Assessment for Intra-Articular Injected Iron Oxide Nanoparticles. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Crowe%2C+L%2E+A%2E%22">Crowe, L. A.</searchLink><relatesTo>1</relatesTo><i> lindsey.crowe@hcuge.ch</i><br /><searchLink fieldCode="AR" term="%22Tobalem%2C+F%2E%22">Tobalem, F.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Gramoun%2C+A%2E%22">Gramoun, A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Delattre%2C+B%2E+M%2E+A%2E%22">Delattre, B. M. A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Grosdemange%2C+K%2E%22">Grosdemange, K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Salaklang%2C+J%2E%22">Salaklang, J.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Redjem%2C+A%2E%22">Redjem, A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Petri-Fink%2C+A%2E%22">Petri-Fink, A.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Hofmann%2C+H%2E%22">Hofmann, H.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Vallée%2C+J%2E+-P%2E%22">Vallée, J. -P.</searchLink><relatesTo>1</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Magnetic+Resonance+in+Medicine%22">Magnetic Resonance in Medicine</searchLink>. Nov2012, Vol. 68 Issue 5, p1544-1552. 9p. – Name: Abstract Label: Abstract Group: Ab Data: The emerging importance of nanoparticle technology, including iron oxide nanoparticles for monitoring development, progression, and treatment of inflammatory diseases such as arthritis, drives development of imaging techniques. Studies require an imaging protocol that is sensitive and quantifiable for the detection of iron oxide over a wide range of concentrations. Conventional signal loss measurements of iron oxide nanoparticle containing tissues saturate at medium concentrations and show a nonlinear/nonproportional intensity to concentration profile due to the competing effects of T1 and T2 relaxation. A concentration calibration phantom and an in vivo study of intra-articular injection in a rat knee of known concentrations of iron oxide were assessed using the difference-ultrashort echo time sequence giving a positive, quantifiable, unambiguous iron signal and monotonic, increasing concentration response over a wide concentration range in the phantom with limited susceptibility artifacts and high contrast in vivo to all other tissues. This improved dynamic response to concentration opens possibilities for quantification due to its linear nature at physiologically relevant concentrations. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Magnetic Resonance in Medicine is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=egs&AN=103682843 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1002/mrm.24166 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 1544 Titles: – TitleFull: Improved Dynamic Response Assessment for Intra-Articular Injected Iron Oxide Nanoparticles. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Crowe, L. A. – PersonEntity: Name: NameFull: Tobalem, F. – PersonEntity: Name: NameFull: Gramoun, A. – PersonEntity: Name: NameFull: Delattre, B. M. A. – PersonEntity: Name: NameFull: Grosdemange, K. – PersonEntity: Name: NameFull: Salaklang, J. – PersonEntity: Name: NameFull: Redjem, A. – PersonEntity: Name: NameFull: Petri-Fink, A. – PersonEntity: Name: NameFull: Hofmann, H. – PersonEntity: Name: NameFull: Vallée, J. -P. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 11 Text: Nov2012 Type: published Y: 2012 Identifiers: – Type: issn-print Value: 07403194 Numbering: – Type: volume Value: 68 – Type: issue Value: 5 Titles: – TitleFull: Magnetic Resonance in Medicine Type: main |
| ResultId | 1 |
