Monitoring Human Occupational and Environmental Exposures to Polycyclic Aromatic Compounds.
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| Title: | Monitoring Human Occupational and Environmental Exposures to Polycyclic Aromatic Compounds. |
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| Authors: | H.C.A. Brandt1, W.P. Watson2 |
| Source: | Annals of Occupational Hygiene. Jul2003, Vol. 47 Issue 5, p349-378. 30p. |
| Subjects: | Biomarkers, Polycyclic aromatic compounds, Diseases |
| Abstract: | Many research groups have been carrying out studies to develop biomarkers of exposure to polycyclic aromatic compounds (PACs) and apply these for human biomonitoring. The main objectives of the use of biomarkers are to determine specific occupational and environmental exposures to monitor the effectiveness of exposure controls and prediction of the risk of disease. This article presents a review of the literature in the field of biomarkers of human exposure to PACs and an evaluation of the relevant biomarkers for monitoring exposure to PACs in a range of exposure situations from coke ovens to bitumen handling and environmental exposures. For this evaluation, the relationships between external PAC exposures and the corresponding biomarker levels have been studied. The literature data indicate that urinary excretion of 1-hydroxypyrene correlates well with external PAC exposure and this compound appears to be a suitable marker for internal exposure to PACs. DNA adducts, mostly measured in white blood cells, do not show satisfactory correlations with exposure to PACs in a variety of workplace and exposure situations. It is not clear which factors are mainly responsible for this poor correlation. Micronuclei and sister chromatid exchanges measured in peripheral white blood cells are also unsatisfactory as biomarkers for PAC exposure. From the relatively limited data available, chromosome aberrations appear to show considerable promise as indicators of exposure to PACs. Because of their strong association with cancer, chromosome aberrations are considered suitable indicators of increased cancer risk arising from exposure to PACs. [ABSTRACT FROM AUTHOR] |
| Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 10407229 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Monitoring Human Occupational and Environmental Exposures to Polycyclic Aromatic Compounds. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22H%2EC%2EA%2E+Brandt%22">H.C.A. Brandt</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22W%2EP%2E+Watson%22">W.P. Watson</searchLink><relatesTo>2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Annals+of+Occupational+Hygiene%22">Annals of Occupational Hygiene</searchLink>. Jul2003, Vol. 47 Issue 5, p349-378. 30p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Biomarkers%22">Biomarkers</searchLink><br /><searchLink fieldCode="DE" term="%22Polycyclic+aromatic+compounds%22">Polycyclic aromatic compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases%22">Diseases</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Many research groups have been carrying out studies to develop biomarkers of exposure to polycyclic aromatic compounds (PACs) and apply these for human biomonitoring. The main objectives of the use of biomarkers are to determine specific occupational and environmental exposures to monitor the effectiveness of exposure controls and prediction of the risk of disease. This article presents a review of the literature in the field of biomarkers of human exposure to PACs and an evaluation of the relevant biomarkers for monitoring exposure to PACs in a range of exposure situations from coke ovens to bitumen handling and environmental exposures. For this evaluation, the relationships between external PAC exposures and the corresponding biomarker levels have been studied. The literature data indicate that urinary excretion of 1-hydroxypyrene correlates well with external PAC exposure and this compound appears to be a suitable marker for internal exposure to PACs. DNA adducts, mostly measured in white blood cells, do not show satisfactory correlations with exposure to PACs in a variety of workplace and exposure situations. It is not clear which factors are mainly responsible for this poor correlation. Micronuclei and sister chromatid exchanges measured in peripheral white blood cells are also unsatisfactory as biomarkers for PAC exposure. From the relatively limited data available, chromosome aberrations appear to show considerable promise as indicators of exposure to PACs. Because of their strong association with cancer, chromosome aberrations are considered suitable indicators of increased cancer risk arising from exposure to PACs. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Annals of Occupational Hygiene is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1093/annhyg/meg052 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 30 StartPage: 349 Subjects: – SubjectFull: Biomarkers Type: general – SubjectFull: Polycyclic aromatic compounds Type: general – SubjectFull: Diseases Type: general Titles: – TitleFull: Monitoring Human Occupational and Environmental Exposures to Polycyclic Aromatic Compounds. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: H.C.A. Brandt – PersonEntity: Name: NameFull: W.P. Watson IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 07 Text: Jul2003 Type: published Y: 2003 Identifiers: – Type: issn-print Value: 00034878 Numbering: – Type: volume Value: 47 – Type: issue Value: 5 Titles: – TitleFull: Annals of Occupational Hygiene Type: main |
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