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Association between carotid plaque enhancement shown by multidetector CT angiography and histologically validated microvessel density.

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Title: Association between carotid plaque enhancement shown by multidetector CT angiography and histologically validated microvessel density.
Authors: Saba L (AUTHOR), Lai ML (AUTHOR), Montisci R (AUTHOR), Tamponi E (AUTHOR), Sanfilippo R (AUTHOR), Faa G (AUTHOR), Piga M (AUTHOR), Saba, Luca1 (AUTHOR), Lai, Maria Letizia (AUTHOR), Montisci, Roberto (AUTHOR), Tamponi, Elisabetta (AUTHOR), Sanfilippo, Roberto (AUTHOR), Faa, Gavino (AUTHOR), Piga, Mario (AUTHOR)
Source: European Radiology. Oct2012, Vol. 22 Issue 10, p2237-2245. 9p.
Abstract: Purpose: Carotid plaques analysed by MDCTA can show contrast enhancement. The purpose of this study was to explore the association between carotid plaque enhancement (CPE) and microvessel density.Materials and Methods: We obtained IRB approval. Twenty-nine consecutive (male, 20; median age, 63) symptomatic patients studied with 16-detector CT were prospectively analysed. Examinations were performed before and after intravenous contrast medium administration, and analysis of plaque enhancement was performed. Patients underwent "en bloc" carotid endarterectomy; histological sections were prepared and the presence of microvessels quantified. Logistic regression analysis as well as ROC curve and area under the curve was calculated.Results: A statistically significant association between the degree of CPE and microvessel density (P = 0.009; rho = 0.553) was observed. The ROC curve analysis confirmed this association with an area under the curve of 0.906, 0.735, 0.644 and 0.546 for CPE of 10 HU, 15 HU, 20 HU and 25 HU respectively. There was a statistically significant difference between the CPE and the degree of neovascularisation (P = 0.0003).Conclusion: Results of this preliminary study suggest that CPE might be associated with the microvessel density. Histological analysis seems to demonstrate that the degree of intra-plaque neo-vascularisation is statistically associated with CPE.Key Points: Carotid artery plaque enhancement at CT is associated with microvessel density. The degree of intra-plaque neo-vascularisation is statistically associated with carotid plaque enhancement. Plaque enhancement at CT should be considered when assessing vulnerable plaques. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Association between carotid plaque enhancement shown by multidetector CT angiography and histologically validated microvessel density.
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  Data: <searchLink fieldCode="AR" term="%22Saba+L%22">Saba L</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai+ML%22">Lai ML</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Montisci+R%22">Montisci R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tamponi+E%22">Tamponi E</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sanfilippo+R%22">Sanfilippo R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faa+G%22">Faa G</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piga+M%22">Piga M</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Saba%2C+Luca%22">Saba, Luca</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Lai%2C+Maria+Letizia%22">Lai, Maria Letizia</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Montisci%2C+Roberto%22">Montisci, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Tamponi%2C+Elisabetta%22">Tamponi, Elisabetta</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sanfilippo%2C+Roberto%22">Sanfilippo, Roberto</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Faa%2C+Gavino%22">Faa, Gavino</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Piga%2C+Mario%22">Piga, Mario</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22European+Radiology%22">European Radiology</searchLink>. Oct2012, Vol. 22 Issue 10, p2237-2245. 9p.
– Name: Abstract
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  Data: <bold>Purpose: </bold>Carotid plaques analysed by MDCTA can show contrast enhancement. The purpose of this study was to explore the association between carotid plaque enhancement (CPE) and microvessel density.<bold>Materials and Methods: </bold>We obtained IRB approval. Twenty-nine consecutive (male, 20; median age, 63) symptomatic patients studied with 16-detector CT were prospectively analysed. Examinations were performed before and after intravenous contrast medium administration, and analysis of plaque enhancement was performed. Patients underwent "en bloc" carotid endarterectomy; histological sections were prepared and the presence of microvessels quantified. Logistic regression analysis as well as ROC curve and area under the curve was calculated.<bold>Results: </bold>A statistically significant association between the degree of CPE and microvessel density (P = 0.009; rho = 0.553) was observed. The ROC curve analysis confirmed this association with an area under the curve of 0.906, 0.735, 0.644 and 0.546 for CPE of 10 HU, 15 HU, 20 HU and 25 HU respectively. There was a statistically significant difference between the CPE and the degree of neovascularisation (P = 0.0003).<bold>Conclusion: </bold>Results of this preliminary study suggest that CPE might be associated with the microvessel density. Histological analysis seems to demonstrate that the degree of intra-plaque neo-vascularisation is statistically associated with CPE.<bold>Key Points: </bold>Carotid artery plaque enhancement at CT is associated with microvessel density. The degree of intra-plaque neo-vascularisation is statistically associated with carotid plaque enhancement. Plaque enhancement at CT should be considered when assessing vulnerable plaques. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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