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Differences in the location and activity of intestinal Crohn's disease lesions between adult and paediatric patients detected with MRI.

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Title: Differences in the location and activity of intestinal Crohn's disease lesions between adult and paediatric patients detected with MRI.
Authors: Maccioni F (AUTHOR), Viola F (AUTHOR), Carrozzo F (AUTHOR), Di Nardo G (AUTHOR), Pino AR (AUTHOR), Staltari I (AUTHOR), Al Ansari N (AUTHOR), Vestri A (AUTHOR), Signore A (AUTHOR), Marini M (AUTHOR), Cucchiara S (AUTHOR), Maccioni, Francesca1 (AUTHOR), Viola, Franca (AUTHOR), Carrozzo, Federica (AUTHOR), Di Nardo, Giovanni (AUTHOR), Pino, Anna Rosaria (AUTHOR), Staltari, Ilaria (AUTHOR), Al Ansari, Najwa (AUTHOR), Vestri, Annarita (AUTHOR), Signore, Alberto (AUTHOR)
Source: European Radiology. Nov2012, Vol. 22 Issue 11, p2465-2477. 13p.
Abstract: Objectives: To prospectively compare paediatric patients (PP) and adult patients (AP) affected by Crohn's disease (CD) in terms of the location and activity of intestinal lesions.Methods: Forty-three children (mean age 15 years) and 43 adults (mean age 48 years) with proven CD underwent magnetic resonance enterography (MRE) to localise lesions and detect their activity in 9 segments of the small and large bowel. The results were analysed on a per patient and per segment basis. Ileo-colonoscopy was performed in all patients. P values less than 0.05 were considered statistically significant.Results: Involvement of terminal ileum was significantly different in the two groups: observed in 100 % of AP (43/43) versus 58 % (23/43) of PP (P < 0.0001). Conversely, the colon was diseased in 84 % of PP versus 64 % of AP. In particular, left colonic segments were significantly more involved in PP (descending colon 53 % versus 21 %, P < 0.01; rectum 67 % versus 23 %, P < 0.0001; sigmoid colon 56 % versus 37 %, not significant), whereas caecal involvement was equal in both groups. In children the maximal disease activity was found in left colonic segments, whereas in adults it was in the terminal ileum.Conclusions: MRE detected significant differences between the two populations, showing a more extensive and severe involvement of the left colon in children but the distal ileum in adults.Key Points: • MRI is useful for assessing Crohn's disease in adult and paediatric patients. • Adult and paediatric patients show different intestinal involvement on MRI. • The distal ileum is maximally involved in adults vs. the left colon in children. • The causes of the severe left colonic disease in children are unknown. • The extensive colonic involvement in children has clinical-diagnostic implications. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Differences in the location and activity of intestinal Crohn&#39;s disease lesions between adult and paediatric patients detected with MRI.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maccioni+F%22&quot;&gt;Maccioni F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Viola+F%22&quot;&gt;Viola F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Carrozzo+F%22&quot;&gt;Carrozzo F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Di+Nardo+G%22&quot;&gt;Di Nardo G&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pino+AR%22&quot;&gt;Pino AR&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Staltari+I%22&quot;&gt;Staltari I&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Al+Ansari+N%22&quot;&gt;Al Ansari N&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vestri+A%22&quot;&gt;Vestri A&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Signore+A%22&quot;&gt;Signore A&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Marini+M%22&quot;&gt;Marini M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Cucchiara+S%22&quot;&gt;Cucchiara S&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Maccioni%2C+Francesca%22&quot;&gt;Maccioni, Francesca&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Viola%2C+Franca%22&quot;&gt;Viola, Franca&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Carrozzo%2C+Federica%22&quot;&gt;Carrozzo, Federica&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Di+Nardo%2C+Giovanni%22&quot;&gt;Di Nardo, Giovanni&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Pino%2C+Anna+Rosaria%22&quot;&gt;Pino, Anna Rosaria&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Staltari%2C+Ilaria%22&quot;&gt;Staltari, Ilaria&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Al+Ansari%2C+Najwa%22&quot;&gt;Al Ansari, Najwa&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Vestri%2C+Annarita%22&quot;&gt;Vestri, Annarita&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Signore%2C+Alberto%22&quot;&gt;Signore, Alberto&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Nov2012, Vol. 22 Issue 11, p2465-2477. 13p.
– Name: Abstract
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  Data: &lt;bold&gt;Objectives: &lt;/bold&gt;To prospectively compare paediatric patients (PP) and adult patients (AP) affected by Crohn&#39;s disease (CD) in terms of the location and activity of intestinal lesions.&lt;bold&gt;Methods: &lt;/bold&gt;Forty-three children (mean age 15&#160;years) and 43 adults (mean age 48&#160;years) with proven CD underwent magnetic resonance enterography (MRE) to localise lesions and detect their activity in 9 segments of the small and large bowel. The results were analysed on a per patient and per segment basis. Ileo-colonoscopy was performed in all patients. P values less than 0.05 were considered statistically significant.&lt;bold&gt;Results: &lt;/bold&gt;Involvement of terminal ileum was significantly different in the two groups: observed in 100&#160;% of AP (43/43) versus 58&#160;% (23/43) of PP (P &lt; 0.0001). Conversely, the colon was diseased in 84&#160;% of PP versus 64&#160;% of AP. In particular, left colonic segments were significantly more involved in PP (descending colon 53&#160;% versus 21&#160;%, P &lt; 0.01; rectum 67&#160;% versus 23&#160;%, P &lt; 0.0001; sigmoid colon 56&#160;% versus 37&#160;%, not significant), whereas caecal involvement was equal in both groups. In children the maximal disease activity was found in left colonic segments, whereas in adults it was in the terminal ileum.&lt;bold&gt;Conclusions: &lt;/bold&gt;MRE detected significant differences between the two populations, showing a more extensive and severe involvement of the left colon in children but the distal ileum in adults.&lt;bold&gt;Key Points: &lt;/bold&gt;• MRI is useful for assessing Crohn&#39;s disease in adult and paediatric patients. • Adult and paediatric patients show different intestinal involvement on MRI. • The distal ileum is maximally involved in adults vs. the left colon in children. • The causes of the severe left colonic disease in children are unknown. • The extensive colonic involvement in children has clinical-diagnostic implications. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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