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Characterization of ductal carcinoma in situ on diffusion weighted breast MRI.

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Title:	Characterization of ductal carcinoma in situ on diffusion weighted breast MRI.
Authors:	Rahbar H (AUTHOR), Partridge SC (AUTHOR), Eby PR (AUTHOR), Demartini WB (AUTHOR), Gutierrez RL (AUTHOR), Peacock S (AUTHOR), Lehman CD (AUTHOR), Rahbar, Habib¹ (AUTHOR), Partridge, Savannah C (AUTHOR), Eby, Peter R (AUTHOR), Demartini, Wendy B (AUTHOR), Gutierrez, Robert L (AUTHOR), Peacock, Sue (AUTHOR), Lehman, Constance D (AUTHOR)
Source:	European Radiology. Sep2011, Vol. 21 Issue 9, p2011-2019. 9p.
Abstract:	Objectives: To characterize ductal carcinoma in situ (DCIS) and its subtypes on diffusion-weighted imaging (DWI).Methods: We retrospectively reviewed 74 pure DCIS lesions in 69 women who underwent DWI at 1.5 T (b = 0 and 600 s/mm(2)). Each lesion was characterized by qualitative DWI intensity, quantitative DWI lesion-to-normal contrast-to-noise ratio (CNR), and quantitative apparent diffusion coefficient (ADC). The detection rate was calculated with predetermined thresholds for each parameter. The effects of lesion size, grade, morphology, and necrosis were assessed.Results: Ninety-six percent (71/74) of DCIS lesions demonstrated greater qualitative DWI intensity than normal breast tissue. Quantitatively, DCIS lesions demonstrated on average 56% greater signal than normal tissue (mean CNR = 1.83 ± 2.7) and lower ADC values (1.50 ± 0.28 × 10(-3) mm(2)/s) than normal tissue (2.01 ± 0.37 × 10(-3) mm(2)/s, p < 0.0001). A 91% detection rate was achieved utilizing an ADC threshold (<1.81 × 10(-3) mm(2)/s ). Non-high-grade DCIS exhibited greater qualitative DWI intensity (p = 0.02) and quantitative CNR (p = 0.01) than high-grade DCIS but no difference in ADC (p = 0.40). Lesion size, morphology, and necrosis did not affect qualitative or quantitative DWI parameters of DCIS lesions (p > 0.05).Conclusions: DCIS lesions have higher DWI signal intensity and lower ADC values than normal breast tissue. DWI warrants further investigation as a potential non-contrast MRI tool for early breast cancer detection. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source
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