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Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction-initial results.

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Title: Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction-initial results.
Authors: Hueper K (AUTHOR), Gutberlet M (AUTHOR), Rodt T (AUTHOR), Gwinner W (AUTHOR), Lehner F (AUTHOR), Wacker F (AUTHOR), Galanski M (AUTHOR), Hartung D (AUTHOR), Hueper, Katja1 (AUTHOR), Gutberlet, M (AUTHOR), Rodt, T (AUTHOR), Gwinner, W (AUTHOR), Lehner, F (AUTHOR), Wacker, F (AUTHOR), Galanski, M (AUTHOR), Hartung, D (AUTHOR)
Source: European Radiology. Nov2011, Vol. 21 Issue 11, p2427-2433. 7p.
Abstract: Objectives: To evaluate MR diffusion tensor imaging (DTI) as non-invasive diagnostic tool for detection of acute and chronic allograft dysfunction and changes of organ microstructure.Methods: 15 kidney transplanted patients with allograft dysfunction and 14 healthy volunteers were examined using a fat-saturated echo-planar DTI-sequence at 1.5 T (6 diffusion directions, b = 0, 600 s/mm²). Mean apparent diffusion coefficient (ADC) and mean fractional anisotropy (FA) were calculated separately for the cortex and for the medulla and compared between healthy and transplanted kidneys. Furthermore, the correlation between diffusion parameters and estimated GFR was determined.Results: The ADC in the cortex and in the medulla were lower in transplanted than in healthy kidneys (p < 0.01). Differences were more distinct for FA, especially in the renal medulla, with a significant reduction in allografts (p < 0.001). Furthermore, in transplanted patients a correlation between mean FA in the medulla and estimated GFR was observed (r = 0.72, p < 0.01). Tractography visualized changes in renal microstructure in patients with impaired allograft function.Conclusions: Changes in allograft function and microstructure can be detected and quantified using DTI. However, to prove the value of DTI for standard clinical application especially correlation of imaging findings and biopsy results is necessary. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Diffusion tensor imaging and tractography for assessment of renal allograft dysfunction-initial results.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hueper+K%22&quot;&gt;Hueper K&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gutberlet+M%22&quot;&gt;Gutberlet M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rodt+T%22&quot;&gt;Rodt T&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gwinner+W%22&quot;&gt;Gwinner W&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lehner+F%22&quot;&gt;Lehner F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wacker+F%22&quot;&gt;Wacker F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Galanski+M%22&quot;&gt;Galanski M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hartung+D%22&quot;&gt;Hartung D&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hueper%2C+Katja%22&quot;&gt;Hueper, Katja&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gutberlet%2C+M%22&quot;&gt;Gutberlet, M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Rodt%2C+T%22&quot;&gt;Rodt, T&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Gwinner%2C+W%22&quot;&gt;Gwinner, W&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lehner%2C+F%22&quot;&gt;Lehner, F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Wacker%2C+F%22&quot;&gt;Wacker, F&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Galanski%2C+M%22&quot;&gt;Galanski, M&lt;/searchLink&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hartung%2C+D%22&quot;&gt;Hartung, D&lt;/searchLink&gt; (AUTHOR)
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Radiology%22&quot;&gt;European Radiology&lt;/searchLink&gt;. Nov2011, Vol. 21 Issue 11, p2427-2433. 7p.
– Name: Abstract
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  Data: &lt;bold&gt;Objectives: &lt;/bold&gt;To evaluate MR diffusion tensor imaging (DTI) as non-invasive diagnostic tool for detection of acute and chronic allograft dysfunction and changes of organ microstructure.&lt;bold&gt;Methods: &lt;/bold&gt;15 kidney transplanted patients with allograft dysfunction and 14 healthy volunteers were examined using a fat-saturated echo-planar DTI-sequence at 1.5 T (6 diffusion directions, b = 0, 600 s/mm&#178;). Mean apparent diffusion coefficient (ADC) and mean fractional anisotropy (FA) were calculated separately for the cortex and for the medulla and compared between healthy and transplanted kidneys. Furthermore, the correlation between diffusion parameters and estimated GFR was determined.&lt;bold&gt;Results: &lt;/bold&gt;The ADC in the cortex and in the medulla were lower in transplanted than in healthy kidneys (p &lt; 0.01). Differences were more distinct for FA, especially in the renal medulla, with a significant reduction in allografts (p &lt; 0.001). Furthermore, in transplanted patients a correlation between mean FA in the medulla and estimated GFR was observed (r = 0.72, p &lt; 0.01). Tractography visualized changes in renal microstructure in patients with impaired allograft function.&lt;bold&gt;Conclusions: &lt;/bold&gt;Changes in allograft function and microstructure can be detected and quantified using DTI. However, to prove the value of DTI for standard clinical application especially correlation of imaging findings and biopsy results is necessary. [ABSTRACT FROM AUTHOR]
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  Data: &lt;i&gt;Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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