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Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia.

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Title: Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia.
Authors: McCommis KS (AUTHOR), Goldstein TA (AUTHOR), Abendschein DR (AUTHOR), Misselwitz B (AUTHOR), Pilgram T (AUTHOR), Gropler RJ (AUTHOR), Zheng J (AUTHOR), McCommis, Kyle S1 (AUTHOR), Goldstein, Thomas A (AUTHOR), Abendschein, Dana R (AUTHOR), Misselwitz, Bernd (AUTHOR), Pilgram, Thomas (AUTHOR), Gropler, Robert J (AUTHOR), Zheng, Jie (AUTHOR)
Source: European Radiology. Aug2010, Vol. 20 Issue 8, p2005-2012. 8p.
Abstract: Objective: To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand.Methods: A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and (99m)Tc-labeled red blood cells were injected to obtain respective gold standards.Results: Microsphere-measured MBF and (99m)Tc-measured MBV reference values correlated well with the MR results. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity.Conclusions: MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion. [ABSTRACT FROM AUTHOR]
Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Roles of myocardial blood volume and flow in coronary artery disease: an experimental MRI study at rest and during hyperemia.
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  Data: <searchLink fieldCode="AR" term="%22McCommis+KS%22">McCommis KS</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goldstein+TA%22">Goldstein TA</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abendschein+DR%22">Abendschein DR</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Misselwitz+B%22">Misselwitz B</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pilgram+T%22">Pilgram T</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gropler+RJ%22">Gropler RJ</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng+J%22">Zheng J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22McCommis%2C+Kyle+S%22">McCommis, Kyle S</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goldstein%2C+Thomas+A%22">Goldstein, Thomas A</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Abendschein%2C+Dana+R%22">Abendschein, Dana R</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Misselwitz%2C+Bernd%22">Misselwitz, Bernd</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Pilgram%2C+Thomas%22">Pilgram, Thomas</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gropler%2C+Robert+J%22">Gropler, Robert J</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zheng%2C+Jie%22">Zheng, Jie</searchLink> (AUTHOR)
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  Data: <bold>Objective: </bold>To validate fast perfusion mapping techniques in a setting of coronary artery stenosis, and to further assess the relationship of absolute myocardial blood volume (MBV) and blood flow (MBF) to global myocardial oxygen demand.<bold>Methods: </bold>A group of 27 mongrel dogs were divided into 10 controls and 17 with acute coronary stenosis. On 1.5-T MRI, first-pass perfusion imaging with a bolus injection of a blood-pool contrast agent was performed to determine myocardial perfusion both at rest and during either dipyridamole-induced vasodilation or dobutamine-induced stress. Regional values of MBF and MBV were quantified by using a fast mapping technique. Color microspheres and (99m)Tc-labeled red blood cells were injected to obtain respective gold standards.<bold>Results: </bold>Microsphere-measured MBF and (99m)Tc-measured MBV reference values correlated well with the MR results. Given the same changes in MBF, changes in MBV are twofold greater with dobutamine than with dipyridamole. Under dobutamine stress, MBV shows better association with total myocardial oxygen demand than MBF. Coronary stenosis progressively reduced this association in the presence of increased stenosis severity.<bold>Conclusions: </bold>MR first-pass perfusion can rapidly estimate regional MBF and MBV. Absolute quantification of MBV may add additional information on stenosis severity and myocardial viability compared with standard qualitative clinical evaluations of myocardial perfusion. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of European Radiology is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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